FB2026_02 , released June 18, 2026
Allele: Dmel\SlnEP2245
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General Information
Symbol
Dmel\SlnEP2245
Species
D. melanogaster
Name
FlyBase ID
FBal0230256
Feature type
allele
Associated gene
Dmel\Sln
Associated Insertion(s)
P{EP}SlnEP2245
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}SlnEP2245
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of SlnEP2245 under the control of Scer\GAL4GMR.PF produces a normal eye phenotype.

        Expression of SlnEP2245 in the developing eye, under the control of Scer\GAL4GMR.PF does not affect neuronal differentiation or levels of apoptosis.

        (Jang et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Enhancer of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Down-regulation of Sln through expression of SlndsRNA.Sym.Scer\UAS in the eye dramatically suppresses the narrow eye phenotype induced by lkb1Scer\UAS.cLa and SlnEP2245 (all under the control of Scer\GAL4GMR.PF).

        (Jang et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference

        Co-expression of BacA\p35Scer\UAS.cHa with both lkb1Scer\UAS.cLa and SlnEP2245 considerably suppresses the apoptotic cell death induced by lkb1Scer\UAS.cLa and SlnEP2245 co-expression in the eye (all under the control of Scer\GAL4GMR.PF).

        (Jang et al., 2008)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        SlnEP1
        (Jang et al., 2008)
        SlnEP2245
        Name Synonyms
        Secondary FlyBase IDs
          References (2)