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Citation
Jang, C., Lee, G., Chung, J. (2008). LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster.  J. Cell Biol. 183(1): 11--17.
FlyBase ID
FBrf0205966
Publication Type
Research paper
Abstract

Silnoon (Sln) is a monocarboxylate transporter (MCT) that mediates active transport of metabolic monocarboxylates such as butyrate and lactate. Here, we identify Sln as a novel LKB1-interacting protein using Drosophila melanogaster genetic modifier screening. Sln expression does not affect cell cycle progression or cell size but specifically enhances LKB1-dependent apoptosis and tissue size reduction. Conversely, down-regulation of Sln suppresses LKB1-dependent apoptosis, implicating Sln as a downstream mediator of LKB1. The kinase activity of LKB1 induces apical trafficking of Sln in polarized cells, and LKB1-dependent Sln trafficking is crucial for triggering apoptosis induced by extracellular butyrate. Given that LKB1 functions to control both epithelial polarity and cell death, we propose Sln is an important downstream target of LKB1.

PubMed ID
PubMed Central ID
PMC2557035 (PMC) (EuropePMC)
Related Publication(s)
Note

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters.
Filippi and Alessi, 2008, J. Cell Biol. 183(1): 7--9 [FBrf0205959]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference