FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SlnRNAi.Sym.UAS
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General Information
Symbol
Dmel\SlnRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0230260
Feature type
allele
Associated gene
Dmel\Sln
Associated Insertion(s)
Carried in Construct
P{UAS-Sln.RNAi.Sym}
Key Links
Transgenic product class
RNAi_reagent
(Jang et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Jang et al., 2008)
Mutagen
in vitro construct
(Jang et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Sln.RNAi.Sym}
Cytology
Description

UAS regulatory sequences drive expression of cDNA against 2072-2565bp of the Sln-coding sequence (corresponding to the 3' region of Sln).

(Jang et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sln
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SlnRNAi.Sym.UAS, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Lkb1UAS.cLa, Scer\GAL4GMR.PF, SlnEP2245

      (Jang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Down-regulation of Sln through expression of SlndsRNA.Sym.Scer\UAS in the eye dramatically suppresses the narrow eye phenotype induced by lkb1Scer\UAS.cLa and SlnEP2245 (all under the control of Scer\GAL4GMR.PF).

      Down-regulation of Sln using two copies of SlndsRNA.Sym.Scer\UAS restores the reduced wing size observed through expression of lkb1Scer\UAS.cLa (under the control of Scer\GAL4Bx-MS1096).

      (Jang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SlnRNAi.Sym.UAS
      SlnSym.Scer\UAS
      SlndsRNA.Sym.Scer\UAS
      SlndsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)