FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lkb1K201I.UAS
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General Information
Symbol
Dmel\Lkb1K201I.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0230261
Feature type
allele
Associated gene
Dmel\Lkb1
Associated Insertion(s)
Carried in Construct
P{UAS-Lkb1.K201I}
Key Links
Transgenic product class
missense_variant
(Lee et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lee et al., 2006)
Mutagen
in vitro construct
(Lee et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Lkb1.K201I}
Cytology
Description

Amino acid replacement: K201I.

(Lee et al., 2006)

UASt regulatory sequences drive expression of kinase-dead Lkb1 coding sequences.

(Lee et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lkb1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye-specific expression of lkb1K201I.Scer\UAS (under the control of Scer\GAL4GMR.PF) does not induce a reduction in overall eye size.

      Dorsal tissue-specific expression of kinase dead lkb1K201I.Scer\UAS (under the control of Scer\GAL4ap-md544) does not affect development.

      Scer\GAL4Bx-MS1096-driven expression of kinase dead lkb1K201I.Scer\UAS dose-dependently has no effect on the overall wing size.

      (Lee et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of SlnEP2245 with lkb1K201I.Scer\UAS in the eye (under the control of Scer\GAL4GMR.PF) does not result in any eye phenotype.

      Co-expression of SlnEP2245 with lkb1K201I.Scer\UAS in the dorsal wing (under the control of Scer\GAL4ap-md544) does not result in any wing phenotype.

      Co-expression of SlnEP2245 with lkb1K201I.Scer\UAS in the wing pouch (under the control of Scer\GAL4Bx-MS1096) does not result in any wing phenotype.

      (Jang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4ap-md544/Lkb1K201I.UAS partially rescues Lkb1UAS.cLa

      (Lee et al., 2006)
      Comments

      A partial downregulation of JNK activity by expression of kinase-dead lkb1K201I.Scer\UAS modestly rescues the adult phenotype induced by Scer\GAL4ap-md544-driven lkb1Scer\UAS.cLa expression.

      (Lee et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      LKB1KI
      (Nguyen et al., 2020)
      Lkb1K201I.Scer\UAS
      Lkb1K201I.UAS
      lkb1K201I.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)