FlyBase Allele Report: Dmel\hppy[17-51]

General Information

Symbol

Dmel\hppy^17-51

Species

D. melanogaster

Name

FlyBase ID

FBal0230289

Feature type

allele

Associated gene

Dmel\hppy

Associated Insertion(s)

P{GawB}hppy^17-51

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Corl et al., 2009)

Progenitor genotype

Associated Insertion(s)

P{GawB}hppy^17-51

Cytology

Description

Insertion 10bp upstream of the transcription start site.

(Corl et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(O'Farrell et al., 2023, Corl et al., 2009)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of alcohol use disorder

is ameliorated by aru^8.128

(Eddison et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant

(Eddison et al., 2011, Corl et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

hppy^17-51 mutants exhibit a decrease in ethanol sensitivity compared to controls.

(Eddison et al., 2011)

Mutant flies show marked resistance to ethanol-induced sedation compared to control flies.

Mutant flies show normal locomotor behaviour and negative geotaxis.

(Corl et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hppy^17-51 has chemical resistant phenotype, suppressible by aru^8.128

(Eddison et al., 2011)

Suppressor of

Statement

Reference

hppy^17-51 is a suppressor of chemical sensitive phenotype of Egfr^GD1654, Scer\GAL4^elav-C155

(Corl et al., 2009)

NOT Suppressor of

Statement

Reference

hppy^17-51 is a non-suppressor of chemical sensitive phenotype of aru^8.128

(Eddison et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The presence of a aru^8.128 background suppresses the ethanol resistance found in hppy^17-51 mutants.

(Eddison et al., 2011)

The increased sensitivity to ethanol-induced sedation caused by expression of Egfr^GD1654 under the control of Scer\GAL4^elav-C155 is completely suppressed by hppy^17-51.

(Corl et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

hppy^KG05537

(Corl et al., 2009)

Rescued by

hppy^17-51 is rescued by hppy^RB.UAS/Scer\GAL4^hppy-17-51

(Corl et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{GawB} element reverts the mutant phenotype.

(Corl et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hppy^17-51

(O'Farrell et al., 2023, Corl et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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