FlyBase Allele Report: Dmel\Ten-m[628]

General Information

Symbol

Dmel\Ten-m⁶²⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0230335

Feature type

allele

Associated gene

Dmel\Ten-m

Associated Insertion(s)

Carried in Construct

Also Known As

odz⁶²⁸

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rakovitsky et al., 2007)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Zheng et al., 2011)

lethal (with Ten-m⁰⁵³⁰⁹)

(Zheng et al., 2011)

lethal (with Ten-m^Δ510)

(Zheng et al., 2011)

lethal (with Ten-m^Δ525)

(Zheng et al., 2011)

lethal | recessive

(Zheng et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos show defects in the guidance of the intersegmental nerve in the periphery.

(Zheng et al., 2011)

Ten-m⁶²⁸ somatic mutant clones generated in the eye and wing are much smaller than their control twin-spots. Ten-m⁶²⁸ somatic clones generated in a Minute/+ background to confer a growth advantage, show abnormal ommatidial shape, size, and order, interommatidial bristle loss, and supernumerary interommatidial bristles at clonal margins. The lens of some ommatidia contains a hole or "breach". One-quarter to one-third of ommatidia lack at least one photoreceptor. Larval eye disc mutant clones show a reduced number of R7 photoreceptor precursor cells.

(Kinel-Tahan et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ten-a³⁶⁷, Ten-m⁶²⁸ has visible phenotype

(Rakovitsky et al., 2007)

Df(1)KA6, Ten-m⁶²⁸ has visible phenotype

(Rakovitsky et al., 2007)

Phenotype Manifest In

Other

Statement

Reference

Df(1)KA6/+, Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Kinel-Tahan et al., 2007)

Ten-a³⁶⁷/Ten-a[+], Ten-m⁶²⁸ has ommatidium phenotype

(Kinel-Tahan et al., 2007)

Ten-a³⁶⁷/Ten-a[+], Ten-m⁶²⁸ has interommatidial bristle phenotype

(Kinel-Tahan et al., 2007)

Ten-a³⁶⁷/Ten-a[+], Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a¹⁵², Ten-m⁶²⁸ has ommatidium phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a¹⁵², Ten-m⁶²⁸ has interommatidial bristle phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a¹⁵², Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a⁹⁵², Ten-m⁶²⁸ has ommatidium phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a⁹⁵², Ten-m⁶²⁸ has interommatidial bristle phenotype

(Kinel-Tahan et al., 2007)

Ten-a[+]/Ten-a⁹⁵², Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Kinel-Tahan et al., 2007)

Df(1)KA6/+, Ten-m⁶²⁸ has ommatidium phenotype

(Kinel-Tahan et al., 2007)

Df(1)KA6/+, Ten-m⁶²⁸ has interommatidial bristle phenotype

(Kinel-Tahan et al., 2007)

Ten-a³⁶⁷, Ten-m⁶²⁸ has ommatidium phenotype

(Rakovitsky et al., 2007)

Ten-a³⁶⁷, Ten-m⁶²⁸ has interommatidial bristle phenotype

(Rakovitsky et al., 2007)

Ten-a³⁶⁷, Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Rakovitsky et al., 2007)

Df(1)KA6, Ten-m⁶²⁸ has ommatidium phenotype

(Rakovitsky et al., 2007)

Df(1)KA6, Ten-m⁶²⁸ has interommatidial bristle phenotype

(Rakovitsky et al., 2007)

Df(1)KA6, Ten-m⁶²⁸ has interommatidial bristle | increased number phenotype

(Rakovitsky et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)KA6; Ten-m⁶²⁸ double heterozygotes show interommatidial bristle loss, supernumerary interommatidial bristles, uneven ommatidial size and shape, column disorder, and interommatidial fusions in 21-40% of adults.

Ten-a³⁶⁷; Ten-m⁶²⁸ double heterozygotes show interommatidial bristle loss, supernumerary interommatidial bristles, uneven ommatidial size and shape, column disorder, and interommatidial fusions in 21-30% of adults.

Ten-a¹⁵²; Ten-m⁶²⁸ double heterozygotes show interommatidial bristle loss, supernumerary interommatidial bristles, uneven ommatidial size and shape, column disorder, and interommatidial fusions in 5-6% of adults.

Ten-a⁹⁵²; Ten-m⁶²⁸ double heterozygotes show interommatidial bristle loss, supernumerary interommatidial bristles, uneven ommatidial size and shape, column disorder, and interommatidial fusions in 5-6% of adults.

(Kinel-Tahan et al., 2007)

Flies with transheterozygous combinations of Ten-a³⁶⁷/+ and Ten-m⁶²⁸/+ as well as Df(1)KA6/+ and Ten-m⁶²⁸/+ display eye roughness. Consistent features include ommatidial order defects, ommatidial fusions, eye sensory bristle loss, and occasional supernumerary sensory bristles.

(Rakovitsky et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (Ten-m⁰⁵³⁰⁹, Df(3L)Ten-m-AL1 and Df(3L)Ten-m-AL29) was in fact due to a mutation present on the balancer in the original stock. The segmentation phenotype described in FBrf0201077 for Ten-m⁶²⁸ has thus been removed from the allele report in FlyBase, since it is likely that this phenotype is due to a second-site mutation rather than the mutation in Ten-m.

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ten-m⁶²⁸

(Zheng et al., 2011)

odz⁶²⁸

(Kinel-Tahan et al., 2007, Rakovitsky et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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