FlyBase Allele Report: Dmel\Sec8[KK101531]

General Information

Symbol

Dmel\Sec8^KK101531

Species

D. melanogaster

Name

FlyBase ID

FBal0231329

Feature type

allele

Associated gene

Dmel\Sec8

Associated Insertion(s)

Carried in Construct

P{KK101531}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101531}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101531

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS

(Chabu and Xu, 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage, with Scer\GAL4^phtm.PO

(Yamanaka et al., 2015)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

some die during larval stage, with Scer\GAL4^phtm.PO

(Yamanaka et al., 2015)

Phenotype Manifest In

NMJ bouton | increased number | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

Detailed Description

Statement

Reference

Expression of Sec8^KK101531 driven by Scer\GAL4^phm.PO leads to developmental delay/arrest at the larval stage.

(Yamanaka et al., 2015)

Cell proliferation is not affected in eye-antennal disc clones expressing Sec8^KK101531 under the control of Scer\GAL4^Act.PU.

(Chabu and Xu, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sec8^KK101531, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Sec8^KK101531, Scer\GAL4^Act.PU is a suppressor of lethal - all die before end of pupal stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sec8^KK101531, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sec8^KK101531 suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

(Chabu and Xu, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105653

P{KK101531}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sec8^KK101531

sec8^KK101531

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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