FlyBase Allele Report: Dmel\Ced-12[KK102788]

General Information

Symbol

Dmel\Ced-12^KK102788

Species

D. melanogaster

Name

FlyBase ID

FBal0232007

Feature type

allele

Associated gene

Dmel\Ced-12

Associated Insertion(s)

Carried in Construct

P{KK102788}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102788}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102788

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

increased cell number | spermatogenesis, with Scer\GAL4^C587

(Zohar-Fux et al., 2022)

Phenotype Manifest In

astrocyte-like glial cell, with Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

gamma Kenyon cell, with Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

spermatogonium | increased number, with Scer\GAL4^C587

(Zohar-Fux et al., 2022)

Detailed Description

Statement

Reference

The expression of Ced-12^KK102788 under the control of Scer\GAL4^c564 has no obvious affect on the inflammatory response to Gram-positive bacterial infection or under basal conditions, as compared to controls.

(Kumar et al., 2016)

Knockdown of Ced-12 in astrocytes, through expression of Ced-12^KK102788 under the control of Scer\GAL4^alrm.PD, leads to a very strong decrease in astrocytic vacuole number and size: vacuole areas are reduced by 90%, and vacuole numbers are rudced by 70% compared with controls. These animals also exhibit a significant accumulation of brp[+] debris in the SOG and the abdominal region of the ventral nerve cord.

Expression of Ced-12^KK102788 under the control of Scer\GAL4^alrm.PD results in a strong suppression of mushroom body γ neuron pruning at 18 hours after pupal formation and a mild phenotype in adults.

(Tasdemir-Yilmaz and Freeman, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ced-12^KK102788, Scer\GAL4^C587 has increased cell number | spermatogenesis phenotype, enhanceable by drpr^Δ5

(Zohar-Fux et al., 2022)

NOT Enhanced by

Statement

Reference

Ced-12^KK102788, Scer\GAL4^alrm.PD has abnormal neuroanatomy phenotype, non-enhanceable by drpr^RNAi.UAS, Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

Enhancer of

Statement

Reference

Scer\GAL4^C587/Ced-12^KK102788 is an enhancer of increased cell number | spermatogenesis phenotype of drpr^Δ5

(Zohar-Fux et al., 2022)

Ced-12^KK102788/Scer\GAL4^alrm.PD is an enhancer of abnormal neuroanatomy phenotype of drpr^Δ5

(Tasdemir-Yilmaz and Freeman, 2014)

NOT Enhancer of

Statement

Reference

Ced-12^KK102788, Scer\GAL4^alrm.PD is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^alrm.PD, drpr^RNAi.UAS

(Tasdemir-Yilmaz and Freeman, 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ced-12^KK102788, Scer\GAL4^C587 has spermatogonium | increased number phenotype, enhanceable by drpr^Δ5

(Zohar-Fux et al., 2022)

NOT Enhanced by

Statement

Reference

Ced-12^KK102788, Scer\GAL4^alrm.PD has astrocyte-like glial cell phenotype, non-enhanceable by drpr^RNAi.UAS, Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

Ced-12^KK102788, Scer\GAL4^alrm.PD has gamma Kenyon cell phenotype, non-enhanceable by drpr^RNAi.UAS, Scer\GAL4^alrm.PD

(Tasdemir-Yilmaz and Freeman, 2014)

Enhancer of

Statement

Reference

Scer\GAL4^C587/Ced-12^KK102788 is an enhancer of spermatogonium | increased number phenotype of drpr^Δ5

(Zohar-Fux et al., 2022)

Ced-12^KK102788/Scer\GAL4^alrm.PD is an enhancer of astrocyte-like glial cell phenotype of drpr^Δ5

(Tasdemir-Yilmaz and Freeman, 2014)

Ced-12^KK102788/Scer\GAL4^alrm.PD is an enhancer of gamma Kenyon cell phenotype of drpr^Δ5

(Tasdemir-Yilmaz and Freeman, 2014)

NOT Enhancer of

Statement

Reference

Ced-12^KK102788, Scer\GAL4^alrm.PD is a non-enhancer of astrocyte-like glial cell phenotype of Scer\GAL4^alrm.PD, drpr^RNAi.UAS

(Tasdemir-Yilmaz and Freeman, 2014)

Ced-12^KK102788, Scer\GAL4^alrm.PD is a non-enhancer of gamma Kenyon cell phenotype of Scer\GAL4^alrm.PD, drpr^RNAi.UAS

(Tasdemir-Yilmaz and Freeman, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of drpr^{dsRNA.Scer\UAS} and Ced-12^KK102788 under the control of Scer\GAL4^alrm.PD does not increase the number of cell bodies or the amount of neurite debris when compared with elimination of each pathway alone.

(Tasdemir-Yilmaz and Freeman, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107590

P{KK102788}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ced-12^KK102788

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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