FlyBase Allele Report: Dmel\Ilp8[KK112161]

General Information

Symbol

Dmel\Ilp8^KK112161

Species

D. melanogaster

Name

FlyBase ID

FBal0237934

Feature type

allele

Associated gene

Dmel\Ilp8

Associated Insertion(s)

Carried in Construct

P{KK112161}

Also Known As

dilp8-RNAi, UAS-dilp8-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112161}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112161

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by yki^{S168A.UAS.EGFP,Tag:HA}

(Yeom et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage, with Scer\GAL4^αTub84B.PL

(Heredia et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^αTub84B.PL-mediated expression of Ilp8^KK112161 shortens the delay in pupariation induced by EMS by 43.24%.

(Garelli et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Ilp8^KK112161 is a suppressor of abnormal developmental rate phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Scer\GAL4^da.G32/Ilp8^KK112161 is a suppressor of decreased occurrence of cell division | larval stage phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Ilp8^KK112161, Scer\GAL4^ey.PH is a suppressor of homeotic | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Ilp8^KK112161, Scer\GAL4^ey.PH is a suppressor of visible | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Ilp8^KK112161, Scer\GAL4^rn-GAL4-5 is a suppressor of abnormal developmental rate phenotype of RpL7^GD11462, Scer\GAL4^rn-GAL4-5

(Colombani et al., 2012)

Ilp8^KK112161, Scer\GAL4^Bx-MS1096 is a suppressor of abnormal developmental rate phenotype of Scer\GAL4^Bx-MS1096, rpr^UAS.C

(Garelli et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Ilp8^KK112161 is a non-suppressor of lethal phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Scer\GAL4^da.G32/Ilp8^KK112161 is a non-suppressor of abnormal size | larval stage phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Ilp8^KK112161, Scer\GAL4^ap-md544 is a non-suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

NLaz^KK107553/Ilp8^KK112161, Scer\GAL4^ap-md544 is a non-suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

Ilp8^KK112161, Scer\GAL4^rn-GAL4-5 is a non-suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Colombani et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Ilp8^KK112161 is a suppressor of larval brain phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Ilp8^KK112161, Scer\GAL4^ey.PH is a suppressor of eye phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Ilp8^KK112161, Scer\GAL4^rn-GAL4-5 is a suppressor of phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Colombani et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Ilp8^KK112161 is a non-suppressor of wing disc | larval stage phenotype of trus^4-15/Df(3R)BSC847

(Takada et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of Ilp8^KK112161 rescues the delay at pupariation of Scer\GAL4^rn-GAL4-5, Syx7^GD2767 animals, but does not suppress their overgrowth phenotype.

Coexpression of Ilp8^KK112161 rescues the delay at pupariation of Scer\GAL4^rn-GAL4-5, RpL7^GD11462 animals.

(Colombani et al., 2012)

The 46.2 +/- 1.3 hours delay in pupariation in rpr^Scer\UAS.C, Scer\GAL4^Bx-MS1096 animals is reverted to a delay of 29.1 +/-2.5 hours by co-expression of Ilp8^KK112161.

(Garelli et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102604

P{KK112161}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG14059^KK112161

Ilp8^KK112161

dilp8-IR^KK

(Heredia et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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