FlyBase Allele Report: Dmel\amon[UAS.cRa]

General Information

Symbol

Dmel\amon^UAS.cRa

Species

D. melanogaster

Name

FlyBase ID

FBal0239242

Feature type

allele

Associated gene

Dmel\amon

Associated Insertion(s)

Carried in Construct

P{UAS-amon.R}

Also Known As

uas-amon

Key Links

Transgenic product class

cDNA

(Rhea et al., 2010)

wild_type

(Rhea et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Rhea et al., 2010)

wild_type

(Rhea et al., 2010)

Mutagen

in vitro construct

(Rhea et al., 2010, Rayburn et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-amon.R}

Cytology

Description

UASt regulatory sequences drive expression of a amon cDNA.

(Rhea et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

amon

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior | adult stage, with Scer\GAL4^Gr28b.b.4.7

(Zhan et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of amon^UAS.cRa under the control of Scer\GAL4^Gr28b.b.4.7 in adults significantly increases food intake, compared to controls.

(Zhan et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

amon^UAS.cRa/Scer\GAL4^Kurs21 rescues Df(3R)Tl-X/amon^C241Y

(Rayburn et al., 2009)

Comments

Restoration of amon function in the CA- and CC-innervating neurons through expression of amon^Scer\UAS.cRa under the control of Scer\GAL4^Kurs21 results in 64% of amon^C241Y mutant larvae completing the molt between first and second instar larvae. Restoring amon expression ot the CA- and CC-innervating is also sufficient to partially rescue growth in amon^C241Y mutants. Rescued amon^C241Y mutant larvae are intermediate in size compared to amon^C241Y mutant and control larvae.