FlyBase Allele Report: Dmel\Snap25[JF02615]

General Information

Symbol

Dmel\Snap25^JF02615

Species

D. melanogaster

Name

FlyBase ID

FBal0239315

Feature type

allele

Associated gene

Dmel\Snap25

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02615}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

(Perkins et al., 2009.8.10)

Progenitor genotype

Carried in construct

P{TRiP.JF02615}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02615

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of epilepsy

CEA

(Deneubourg et al., 2025)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

model of epilepsy

is ameliorated by Epg5^KO

(Deneubourg et al., 2025)

ameliorates Vici syndrome

modeled by Epg5^KO

(Deneubourg et al., 2025)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PG

(Peng et al., 2015)

fertile, with Scer\GAL4^Tub.PU

(Syrzycka et al., 2019)

viable, with Scer\GAL4^Tub.PU

(Syrzycka et al., 2019)

Phenotype Manifest In

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PG

(Peng et al., 2015)

Detailed Description

Statement

Reference

Expression of Snap25^JF02615 RNAi under the control of Scer\GAL4^ppk.PG results in a significant decrease in the number of terminal dendritic branches in the third instar larval stage class IV dendrite arborizing neurons.

(Peng et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Snap25^JF02615, Scer\GAL4^elav.PU is an enhancer of paralytic | adult stage | heat sensitive phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Snap25^JF02615, Scer\GAL4^elav.PU is an enhancer of abnormal heat stress response | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27306

y¹ v¹; P{TRiP.JF02615}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Snap25^JF02615

Snap25^RNAi

(Kacsoh et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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