FlyBase Allele Report: Dmel\apolpp[HM05157]

General Information

Symbol

Dmel\apolpp^HM05157

Species

D. melanogaster

Name

FlyBase ID

FBal0240286

Feature type

allele

Associated gene

Dmel\apolpp

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05157}

Also Known As

apolpp^RNAi, apolpp RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05157}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05157

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | adult stage | female, with Scer\GAL4^Lsp2.3.1

(Matsuoka et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing apolpp^HM05157 under the control of Scer\GAL4^DcG leads to third instar larval fat cells exhibiting an increase in the size and a decrease in the density of peripheral lipid droplets, compared to controls; there are no changes in cytoplasmic medial lipid droplet size or density.

(Ugrankar et al., 2019)

Expression of apolpp^HM05157 under the control of Scer\GAL4^Lsp2.3.1 (using tub-Gal80[ts] to limit expression to adulthood) results in highly increased cell death in vitellogenic stage follicles (but not germaria) and also increases the rate of loss of the germline stem cells over time.

(Matsuoka et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

apolpp^HM05157, Scer\GAL4^NP0001 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

apolpp^HM05157, Scer\GAL4^NP0001 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^KK115582, Scer\GAL4^NP0001