FlyBase Allele Report: Dmel\tal[ORF1.UAS]

General Information

Symbol

Dmel\tal^ORF1.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0241053

Feature type

allele

Associated gene

tal

Associated Insertion(s)

Carried in Construct

P{UAS-pri.ORF1}

Key Links

Transgenic product class

wild_type

(Kondo et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kondo et al., 2007)

Mutagen

in vitro construct

(Kondo et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-pri.ORF1}

Cytology

Description

UASt regulatory sequences drive expression of the tal-1A open reading frame of tal.

(Kondo et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

tal

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

external sensory organ | ectopic, with Scer\GAL4^dpp.blk1

(Pi et al., 2011)

mesonotum, with Scer\GAL4^dpp.blk1

(Pi et al., 2011)

wing vein | somatic clone, with Scer\GAL4^FRT.Act5C

(Pi et al., 2011)

wing vein L3, with Scer\GAL4^dpp.blk1

(Pi et al., 2011)

Detailed Description

Statement

Reference

Expression of tal^{ORF1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 results in a few ectopic external sensory organs.

Expression of tal^{ORF1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 induces mild but detectable L3 vein expansion at the distal tip (even at 18[o]C).

Ectopic tal^{ORF1.Scer\UAS} expressing clones (under the control of Scer\GAL4^{Scer\FRT.Act5C}) exhibit overlapping wing veins. A third of these display a wing vein expansion phenotype.

(Pi et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^dpp.blk1, tal^ORF1.UAS has external sensory organ | ectopic phenotype, enhanceable by phyl^UAS.cPa/Scer\GAL4^dpp.blk1

(Pi et al., 2011)

Scer\GAL4^dpp.blk1, tal^ORF1.UAS has mesonotum phenotype, enhanceable by phyl^UAS.cPa/Scer\GAL4^dpp.blk1

(Pi et al., 2011)

Scer\GAL4^dpp.blk1, tal^ORF1.UAS has wing vein L3 phenotype, enhanceable by phyl^UAS.cPa/Scer\GAL4^dpp.blk1

(Pi et al., 2011)

Enhancer of

Statement

Reference

Scer\GAL4^dpp.blk1/tal^ORF1.UAS is an enhancer of external sensory organ | ectopic phenotype of Scer\GAL4^dpp.blk1, phyl^UAS.cPa

(Pi et al., 2011)

Scer\GAL4^dpp.blk1/tal^ORF1.UAS is an enhancer of mesonotum phenotype of Scer\GAL4^dpp.blk1, phyl^UAS.cPa

(Pi et al., 2011)

Scer\GAL4^dpp.blk1/tal^ORF1.UAS is an enhancer of wing vein L3 phenotype of phyl^UAS.cPa

(Pi et al., 2011)

Scer\GAL4^dpp.blk1/tal^ORF1.UAS is an enhancer of wing phenotype of N^55e11

(Pi et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of tal^{ORF1.Scer\UAS} with phyl^Scer\UAS.cPa, both under the control of Scer\GAL4^dpp.blk1, induces as many as 7.2 (+/- 1.4) ectopic external sensory organs.

Co-expression of tal^{ORF1.Scer\UAS} with phyl^Scer\UAS.cPa, both under the control of Scer\GAL4^dpp.blk1, results in strong L3 wing vein expansion and formation of a large number of external sensory organs on the L3 vein.

Expression of tal^{ORF1.Scer\UAS} by Scer\GAL4^dpp.blk1 enhances the wing-notching phenotype found in N^55e11 heterozygotes.

(Pi et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^arm.PS/tal^ORF1.UAS rescues tal^pri-2/tal^pri-1

(Kondo et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tal^{ORF1.Scer\UAS}

tal^ORF1.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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