FlyBase Allele Report: Dmel\kirre[sps-1]

General Information

Symbol

Dmel\kirre^sps-1

Species

D. melanogaster

Name

FlyBase ID

FBal0241103

Feature type

allele

Associated gene

Dmel\kirre

Associated Insertion(s)

Carried in Construct

Also Known As

Df(1)duf^sps-1, Df(1)Duf^sps1

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Weavers et al., 2009)

Mutagen

Progenitor genotype

Cytology

Description

A small deficiency that removes the kirre locus only.

(Weavers et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Osaka et al., 2024)

Phenotype Manifest In

embryonic/larval garland cell | third instar larval stage

(Helmstadter et al., 2012)

filtration diaphragm

(Tutor et al., 2014)

lamina monopolar neuron L2

(Osaka et al., 2024)

nucleus | increased number | third instar larval stage

(Helmstadter et al., 2012)

pericardial cell

(Tutor et al., 2014)

synapse | decreased number

(Osaka et al., 2024)

Detailed Description

Statement

Reference

kirre^sps-1 mutant nephrocytes lack filtration diagrams and agglutination of nephrocytes is observed.

(Tutor et al., 2014)

kirre^sps-1 mutant garland cell nephrocytes (GCNs) show a severe hyperfusion phenotype characterised by multinucleate GCNs.

(Helmstadter et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

kirre^sps-1 is a suppressor of abnormal neuroanatomy phenotype of side-IV^Δ4-2/side-IV^Δ4-1

(Osaka et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

kirre^sps-1 has embryonic/larval garland cell | third instar larval stage phenotype, suppressible by Scer\GAL4^sns.GCN/Mmus\Kirrel^UAS.Tag:V5

(Helmstadter et al., 2012)

kirre^sps-1 has nucleus | increased number | third instar larval stage phenotype, suppressible by Scer\GAL4^sns.GCN/Mmus\Kirrel^UAS.Tag:V5

(Helmstadter et al., 2012)

NOT suppressed by

Statement

Reference

kirre^sps-1 has embryonic/larval garland cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^sns.GCN/Mmus\Kirrel3^UAS.Tag:V5

(Helmstadter et al., 2012)

kirre^sps-1 has nucleus | increased number | third instar larval stage phenotype, non-suppressible by Scer\GAL4^sns.GCN/Mmus\Kirrel3^UAS.Tag:V5

(Helmstadter et al., 2012)

kirre^sps-1 has embryonic/larval garland cell | third instar larval stage phenotype, non-suppressible by Mmus\Kirrel2^UAS.Tag:V5/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

kirre^sps-1 has nucleus | increased number | third instar larval stage phenotype, non-suppressible by Mmus\Kirrel2^UAS.Tag:V5/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

Suppressor of

Statement

Reference

kirre^sps-1 is a suppressor of synapse | ectopic phenotype of side-IV^Δ4-2/side-IV^Δ4-1

(Osaka et al., 2024)

kirre^sps-1 is a suppressor of lamina monopolar neuron L2 phenotype of side-IV^Δ4-2/side-IV^Δ4-1

(Osaka et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The garland cell phenotype associated with kirre^sps-1 mutants is not suppressed by the expression of Mmus\Kirrel2^{Scer\UAS.T:SV5\V5} using Scer\GAL4^sns.GCN.

The garland cell phenotype associated with kirre^sps-1 mutants is not suppressed by the expression of Mmus\Kirrel3^{Scer\UAS.T:SV5\V5} using Scer\GAL4^sns.GCN.

The garland cell phenotype associated with kirre^sps-1 mutants is suppressed by the expression of Mmus\Kirrel^{Scer\UAS.T:SV5\V5} using Scer\GAL4^sns.GCN.

(Helmstadter et al., 2012)

Complementation and Rescue Data

Rescued by

kirre^sps-1 is rescued by Scer\GAL4^sns.GCN/kirre^UAS.GFP

(Tutor et al., 2014)

kirre^sps-1 is rescued by Scer\GAL4^sns.GCN/kirre^UAS.cRa

(Helmstadter et al., 2012)

Partially rescued by

kirre^sps-1 is partially rescued by Scer\GAL4^sns.GCN/kirre^{Y810A.UAS.GFP}

(Tutor et al., 2014)

kirre^sps-1 is partially rescued by kirre^{ΔCT1.UAS.Tag:FLAG}/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

kirre^sps-1 is partially rescued by kirre^{ΔCT2.UAS.Tag:FLAG}/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

kirre^sps-1 is partially rescued by kirre^{ΔCT3.UAS.Tag:FLAG}/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

Not rescued by

kirre^sps-1 is not rescued by kirre^ext.UAS.GFP/Scer\GAL4^sns.GCN

(Tutor et al., 2014)

kirre^sps-1 is not rescued by kirre^{Δ610-959.UAS.Tag:FLAG}/Scer\GAL4^sns.GCN

(Helmstadter et al., 2012)

Comments

Expression of kirre^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sns.GCN fully rescues the nephrocyte phenotypes seen in kirre^sps-1 mutant flies.

Expression of kirre^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sns.GCN is unable to rescue the nephrocyte phenotypes seen in kirre^sps-1 mutant flies.

Expression of kirre^{Y810A.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sns.GCN partially rescues the nephrocyte phenotypes seen in kirre^sps-1 mutant flies.

(Tutor et al., 2014)

The garland cell phenotype associated with kirre^sps-1 mutants is rescued by the expression of kirre^Scer\UAS.cRa using Scer\GAL4^sns.GCN.

Expression of kirre^{ΔCT1.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^sns.GCN partially rescues the garland cell phenotype associated with kirre^sps-1 mutants.

Expression of kirre^{ΔCT2.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^sns.GCN partially rescues the garland cell phenotype associated with kirre^sps-1 mutants.

Expression of kirre^{ΔCT3.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^sns.GCN partially rescues the garland cell phenotype associated with kirre^sps-1 mutants.

Expression of kirre^{Δ610-959.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^sns.GCN fails to rescue the garland cell phenotype associated with kirre^sps-1 mutants.

(Helmstadter et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Df(1)Duf^sps1

(Carrasco-Rando et al., 2019, Tutor et al., 2014)

Df(1)duf_sps-1

(Li et al., 2026)

Df(1)duf^sps-1

(Helmstadter et al., 2012, Sugie et al., 2010, Weavers et al., 2009)

Df(1)duf^sps1

(Tutor et al., 2014)

duf^sps1

(Castillo-Mancho et al., 2024)

kirre^sp-1

(Lee et al., 2023)

kirre^sps-1

kirre^sps

(Osaka et al., 2024)

sps1

(Tutor et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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