FB2026_02 , released June 18, 2026
Allele: Dmel\atlUAS.cLa
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General Information
Symbol
Dmel\atlUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lee
FlyBase ID
FBal0241128
Feature type
allele
Associated gene
Dmel\atl
Associated Insertion(s)
Carried in Construct
P{UAS-atl.L}
Also Known As
UAS-atl
Key Links
Transgenic product class
cDNA
(Lee et al., 2008)
wild_type
(Lee et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lee et al., 2008)
wild_type
(Lee et al., 2008)
Mutagen
in vitro construct
(Lee et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-atl.L}
Cytology
Description

UAS regulatory sequences drive expression of a 3125bp atl cDNA fragment.

(Lee et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
atl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval somatic muscle cell, with Scer\GAL4C57

      (Lee et al., 2009)

      microtubule & embryonic/larval somatic muscle, with Scer\GAL4C57

      (Lee et al., 2009)
      Detailed Description
      Statement
      Reference

      Expression of atlScer\UAS.cLa under the control of Scer\GAL4C57 results in a significant reduction of microtubules in the body wall muscles of larvae. Partial or complete detachment of muscles from their attachment sites is also seen, resulting in defects in muscle shape.

      (Lee et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4C57, atlUAS.cLa has larval somatic muscle cell phenotype, suppressible by spas5.75/spas5.75

      (Lee et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The muscle defects seen in larvae expressing atlScer\UAS.cLa under the control of Scer\GAL4C57 are suppressed by spas5.75/spas5.75.

      (Lee et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      atlUAS.cLa/Scer\GAL4elav-C155 rescues atl1

      (Lee et al., 2008)
      Partially rescues

      atlUAS.cLa/Scer\GAL4C57 partially rescues Df(3R)Exel7357/atl2

      (Lee et al., 2009)

      atlUAS.cLa/Scer\GAL4ple.PF partially rescues atl1

      (Lee et al., 2008)

      atlUAS.cLa/Scer\GAL4DAT.PL partially rescues atl1

      (Lee et al., 2008)

      atlUAS.cLa/Scer\GAL4Ddc.PL partially rescues atl1

      (Lee et al., 2008)
      Fails to rescue

      atlUAS.cLa/Scer\GAL4elav-C155 fails to rescue Df(3R)Exel7357/atl2

      (Lee et al., 2009)

      atlUAS.cLa/Scer\GAL4ChAT.Switch.PL fails to rescue atl1

      (Lee et al., 2008)
      Comments

      Expression of atlScer\UAS.cLa under the control of Scer\GAL4C57 at 18[o]C partially restores the reduction of the combined surface area of muscles 6 and 7 of segment A2 that is seen in atl2/Df(3R)Exel7357 larvae. In addition, the bouton number/muscle area is completely rescued and dense clusters of boutons are rarely seen in the rescued animals.

      Expression of atlScer\UAS.cLa under the control of Scer\GAL4elav-C155 at 18[o]C does not rescue either bouton number or muscle size in atl2/Df(3R)Exel7357 larvae.

      (Lee et al., 2009)

      Expression of atlScer\UAS.cLa under the control of either Scer\GAL4ple.PF, Scer\GAL4DAT.PL or Scer\GAL4Ddc.PL partially rescues the ability of atl1 flies to climb after vortexing. In addition, the rescued flies do not show age-dependent degeneration of dopaminergic neurons even 15 days after eclosion.

      Expression of atlScer\UAS.cLa under the control of Scer\GAL4Cha.Switch.PL does not rescue the climbing ability of atl1 flies after vortexing.

      Expression of atlScer\UAS.cLa under the control of Scer\GAL4elav-C155 almost completely rescues the ability of atl1 flies to climb after vortexing.

      (Lee et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      atlScer\UAS.cLa
      atlUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lee
      Secondary FlyBase IDs
        References (2)