FlyBase Allele Report: Dmel\Dis3[G5039]

General Information

Symbol

Dmel\Dis3^G5039

Species

D. melanogaster

Name

FlyBase ID

FBal0241416

Feature type

allele

Associated gene

Dmel\Dis3

Associated Insertion(s)

P{EP}Dis3^G5039

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bellen, 2010.2.4)

Progenitor genotype

Associated Insertion(s)

P{EP}Dis3^G5039

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:24,333,435..24,333,435 [+]

(Bellen, 2010.2.4)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates multiple myeloma

modeled by Dis3¹

(Snee et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number (with Df(3R)BSC638)

(Snee et al., 2016)

increased cell number (with Dis3¹)

(Snee et al., 2016)

increased cell number (with Dis3²)

(Snee et al., 2016)

semi-sterile (with Df(3R)BSC638)

(Snee et al., 2016)

semi-sterile (with Dis3¹)

(Snee et al., 2016)

semi-sterile (with Dis3²)

(Snee et al., 2016)

viable (with Df(3R)BSC638)

(Snee et al., 2016)

viable (with Dis3¹)

(Snee et al., 2016)

viable (with Dis3²)

(Snee et al., 2016)

Phenotype Manifest In

follicle cell | increased number (with Df(3R)BSC638)

(Snee et al., 2016)

follicle cell | increased number (with Dis3¹)

(Snee et al., 2016)

follicle cell | increased number (with Dis3²)

(Snee et al., 2016)

Detailed Description

Statement

Reference

Dis3^G5039/Df(3R)BSC638, Dis3^G5039/Dis3¹ or Dis3^G5039/Dis3² flies are viable, largely infertile and morphologically normal (apart from small bristles and occasional crumpled wings); a large percentage of stage 5-6 egg chambers show over proliferation, with excess posterior follicle cells (follicle cell polarity is grossly normal).

(Snee et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dis3²/Dis3^G5039 has increased cell number phenotype, suppressible by grk³/grk^2B6

(Snee et al., 2016)

Suppressor of

Statement

Reference

Dis3[+]/Dis3^G5039 is a suppressor of chemical sensitive | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

Dis3[+]/Dis3^G5039 is a suppressor of increased mortality | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dis3²/Dis3^G5039 has follicle cell | increased number phenotype, suppressible by grk³/grk^2B6

(Snee et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

grk³/grk^2B6 suppresses the over proliferation of posterior follicle cells in Dis3^G5039/Dis3² egg chambers.

(Snee et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dis3¹/Dis3^G5039 is rescued by Scer\GAL4^Act.PU/Dis3^G5039

(Snee et al., 2016)

Dis3²/Dis3^G5039 is rescued by Scer\GAL4^Act.PU/Dis3^G5039

(Snee et al., 2016)

Rescues

Scer\GAL4^Act.PU/Dis3^G5039 rescues Dis3¹/Dis3^G5039

(Snee et al., 2016)

Scer\GAL4^Act.PU/Dis3^G5039 rescues Dis3²/Dis3^G5039

(Snee et al., 2016)

Comments

Expression of Dis3^G5039 driven by Scer\GAL4^Act.PU rescues over proliferation of follicle cell phenotypes in Dis3^G5039/Dis3¹ or Dis3^G5039/Dis3² egg chambers.

(Snee et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30112

w¹¹¹⁸; P{EP}Dis3^G5039

Notes on Origin

Discoverer

Separable from: a second site lethal mutation on the chromosome (homozygotes are lethal, but the chromosome is viable over Df(3R)BSC638, a deficiency which removes Dis3).

(Snee et al., 2016)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dis3^G5039

(Ribot et al., 2022, Bellen, 2010.2.4)

Dis3^ep

(Villa et al., 2024)

dis3^G5039

(Snee et al., 2016)

dis3^P

(Snee et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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