FB2026_02 , released June 18, 2026
Allele: Dmel\ApplsdΔE2.UAS
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General Information
Symbol
Dmel\ApplsdΔE2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241475
Feature type
allele
Associated gene
Dmel\Appl
Associated Insertion(s)
Carried in Construct
P{UAS-Appl.sdΔE2}
Key Links
Transgenic product class
inframe_deletion
(Torroja et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Torroja et al., 1999)
Mutagen
in vitro construct
(Merdes et al., 2004, Torroja et al., 1999)
Progenitor genotype
ApplUAS.cTa
(Torroja et al., 1999)
Applsd.UAS
(Merdes et al., 2004)
Carried in construct
P{UAS-Appl.sdΔE2}
Cytology
Description

Deletion of part of the extracellular domain 2 (amino acids 449-740) as well as the cleavage site (therefore protein tethered to membrane) of the Appl coding region.

(Torroja et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Appl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEA
      (Rieche et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When Applsd.Scer\UAS is driven by Scer\GAL4sca-537.4 a strong bristle transformation phenotype is seen.

      (Merdes et al., 2004)

      When expression is driven in the motoneurons muscles 6 and 7 (abdominal segment 3) total number of synaptic boutons is slightly increased, percentage of satellite boutons is increased and the number of normal boutons is slightly increased.

      (Torroja et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Applsd.ΔE2.Scer\UAS
      ApplsdΔE2.Scer\UAS
      ApplsdΔE2.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0103094
      • FBal0188191
      References (5)