FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-let7Δ.cSa
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General Information
Symbol
Dmel\mir-let7Δ.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0241769
Feature type
allele
Associated gene
Dmel\mir-let7
Associated Insertion(s)
Carried in Construct
P{W8,let7CΔmir-let7}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Sokol et al., 2008)
Progenitor genotype
mir-let7+tSa
(Sokol et al., 2008)
Carried in construct
P{W8,let7CΔmir-let7}
Cytology
Description

The let-7 seed sequence (GAGGTAGTAGGTT) has been deleted.

(Sokol et al., 2008)
Allele components
Component
Use(s)
Encoded product / tool
mir-let7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals lacking let-7 function (Df(2L)let-7-CKO1/Df(2L)let-7-CGKI animals carrying P{W8,let-7-CΔlet-7}) show a significant reduction in the volume of the mushroom body α/β lobes compared to wild type. The lobes may appear slim or underdeveloped, axonal projections may be misguided or the β lobes may be fused. These animals show a significant reduction in olfactory short-term memory compared to wild type.

      (Kucherenko et al., 2012)

      Homozygous let-7Δ.cSa mutant flies show decreased locomotor activity and specific decrease in dopaminergic neurons.

      (Gehrke et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      mir-let7Δ.cSa has abnormal neuroanatomy | recessive phenotype, suppressible by Dp[+]/Dp49Fk-1

      (Gehrke et al., 2010)

      mir-let7Δ.cSa has abnormal neuroanatomy | recessive phenotype, suppressible by E2f[+]/E2f107172

      (Gehrke et al., 2010)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      mir-let7Δ.cSa has dopaminergic neuron phenotype, suppressible by Dp[+]/Dp49Fk-1

      (Gehrke et al., 2010)

      mir-let7Δ.cSa has dopaminergic neuron phenotype, suppressible by E2f[+]/E2f107172

      (Gehrke et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Dp49Fk-1 suppresses the dopaminergic neuronal phenotypes of homozygous let-7Δ.cSa animals.

      Heterozygosity for E2f07172 suppresses the dopaminergic neuronal phenotypes of homozygous let-7Δ.cSa animals.

      (Gehrke et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mir-let7Δ.cSa is rescued by mir-let7+tSa

      (Gehrke et al., 2010)
      Comments

      The neurological phenotypes of homozygous let-7Δ.cSa mutants can be rescued by let-7+tSa.

      (Gehrke et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      let-7Δ.cSa
      mir-let7Δ.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (6)