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General Information
Symbol
Dmel\Inx2JF02446
Species
D. melanogaster
Name
FlyBase ID
FBal0242150
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
JF02446
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Inx2JF02446 under the control of Scer\GAL4ey-OK107 in adults does not significantly affect 3 hour aversive olfactory memory, compared to controls.

Expression of Inx2JF02446 under the control of Scer\GAL4repo.PL (in combination with tub-Gal80[ts] transgene to restrict expression to the adult stage) leads to a significantly reduced life span under sugar only diet when compared to controls.

Expression of Inx2JF02446 under the control of Scer\GAL4tj.PU (along with expression of UAS-Dcr2 to increase RNAi efficiency) results in disruption of spermatogenesis, sterility and small, rudimentary testes. Germline stem cell number in testes is significantly reduced, early somatic cell number is increased, and late somatic cell number is decreased. Somatic cyst stem cell proliferation is disrupted. The number of germline cysts that reach meiotic stages is reduced. Encapsulation of testis germline cysts occurs normally, and cadherin-mediated cell-cell adhesion is unaffected in testes expressing Inx2JF02446 under the control of Scer\GAL4tj.PU.

Neuronal expression of Inx2JF02446 under the control of Scer\GAL4elav-C155 does not affect fly viability or visual signal transmission.

Expression of Inx2JF02446 using Scer\GAL4Mz709 does not cause obvious morphological change to satellite glia. These flies show normal arrays of ommatidia and cartridges in the retina and lamina, respectively. In the lamina, fine structures such as capitate projections and T-bar synapses appear normal in photoreceptor terminals. However, photoreceptor terminals exhibit a reduced number of synaptic vesicles. The density of these synaptic vesicles is approximately 50% of wild-type.

Knockdown of Inx2 through expression of Inx2JF02446 using Scer\GAL4Mz709 results in the absence of ON and OFF transients in ERG recordings of the laminar LMC neurons at the onset and end of light stimulation.

Expression of Inx2JF02446 under the control of Scer\GAL4ptc-559.1 has no effect on the wing margin.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Inx2JF02446 and Inx3HM05245, both under the control of Scer\GAL4tj.PU, phenocopies expression of Inx2JF02446 alone under the control of Scer\GAL4tj.PU.

Co-expression of GmdNIG.8890R and Inx2JF02446 under the control of Scer\GAL4ptc-559.1 results in loss of wing margin.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of Inx2Scer\UAS.T:Avic\GFP-EGFP in glia, under the control of Scer\GAL4repo, partially rescues flies expressing Inx2JF02446 under the control of Scer\GAL4repo. These rescued flies show normal visual transmission, excluding a role of neuronal Inx2 in visual transmission.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Inx2JF02446
Inx2TripJF02446
Name Synonyms
Secondary FlyBase IDs
    References (8)