FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\CAG41Q.UAS.Tag:HA
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General Information
Symbol
Zzzz\CAG41Q.UAS.Tag:HA
Species
a. artificial
Name
FlyBase ID
FBal0243413
Feature type
allele
Associated gene
Zzzz\CAG
Associated Insertion(s)
Carried in Construct
P{UAS-41Q.HA}
Also Known As
UAS-41Q, UAS-41Q-HA
Transgenic product class
trinucleotide_repeat_expansion
(Fayazi et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Fayazi et al., 2006)
Mutagen
in vitro construct
(Fayazi et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-41Q.HA}
Cytology
Description

UAS regulatory sequences drive expression of a expression of a 41 amino acid polyglutamine repeat, which is tagged at the C-terminal end with Tag:HA.

(Fayazi et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Zzzz\CAG
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Chou et al., 2021, Yeh et al., 2018)
      CEC
      (Chen et al., 2012)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by Ptpmeg2UAS.Tag:FLAG
      (Chou et al., 2021)
      is ameliorated by Atg7UAS.cCa
      (Chen et al., 2012)
      is exacerbated by Atg7GD11671
      (Chen et al., 2012)
      is exacerbated by Hsp27GD11327
      (Chen et al., 2012)
      is ameliorated by Hsp27UAS.Tag:HA
      (Chen et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU results in a mild mosaic eye pigmentation defect.

      (Chen et al., 2012)

      Retinas appear disorganised in 5 week old flies expressing Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ninaE.PD.

      (Fayazi et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The mild mosaic eye pigmentation defect caused by expression of Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is rescued by co-expression of either Hsp27Scer\UAS.T:Ivir\HA1 or Atg7Scer\UAS.cCa.

      The mild mosaic eye pigmentation defect caused by expression of Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is enhanced by co-expression of either Hsp27GD11327 or Atg7GD11671. In the case of Atg7GD11671 a rough eye phenotype is also seen.

      (Chen et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Zzzz\CAG41Q.Scer\UAS.T:Ivir\HA1
      Zzzz\CAG41Q.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (7)