FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\qvrUAS.cWa
Open Close
General Information
Symbol
Dmel\qvrUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wu
FlyBase ID
FBal0243448
Feature type
allele
Associated gene
Dmel\qvr
Associated Insertion(s)
Carried in Construct
P{UAS-qvr.W}
Also Known As
UAS-sss
Key Links
Transgenic product class
wild_type
(Wu et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2010)
Mutagen
in vitro construct
(Wu et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-qvr.W}
Cytology
Description

UAS regulatory sequences drive expression of the entire coding region of qvr/

(Wu et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
qvr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      qvrUAS.cWa/Scer\GAL4elav.PLu rescues qvrΔ40/qvrEY04063

      (Zhou et al., 2023)

      qvrUAS.cWa/Scer\GAL4nSyb.PS rescues qvrΔ40/qvrEY04063

      (Zhou et al., 2023)

      Scer\GAL4Tub.PU/qvrUAS.cWa rescues qvrΔ40/qvrEY04063

      (Zhou et al., 2023)

      Scer\GAL4qvr.PW/qvrUAS.cWa rescues qvrEY04063

      (Wu et al., 2014)

      Scer\GAL4qvr.PW/qvrUAS.cWa rescues qvrEY04063

      (Wu et al., 2010)
      Partially rescues

      Scer\GAL4elav.Switch.PO/qvrUAS.cWa partially rescues qvrEY04063

      (Chen et al., 2015)

      Scer\GAL4Gad1.3.098/qvrUAS.cWa partially rescues qvrEY04063

      (Chen et al., 2015)

      Scer\GAL4VGAT.PF/qvrUAS.cWa partially rescues qvrEY04063

      (Chen et al., 2015)

      Scer\GAL4repo.PU/qvrUAS.cWa partially rescues qvrEY04063

      (Chen et al., 2015)

      Scer\GAL4elav-C155/qvrUAS.cWa partially rescues qvrEY04063

      (Wu et al., 2010)

      qvrUAS.cWa/Scer\GAL4ChAT.7.4 partially rescues qvrEY04063

      (Wu et al., 2010)

      Scer\GAL4how-24B/qvrUAS.cWa partially rescues qvrEY04063

      (Wu et al., 2010)

      qvrUAS.cWa/Scer\GAL4VGlut1.PS partially rescues qvrEY04063

      (Wu et al., 2010)
      Fails to rescue

      Scer\GAL4Gabat-PL00338/qvrUAS.cWa fails to rescue qvrEY04063

      (Chen et al., 2015)

      Scer\GAL4ple.PF/qvrUAS.cWa fails to rescue qvrEY04063

      (Wu et al., 2010)
      Comments

      Restoring qvrScer\UAS.cWa specifically in adults (driven by Scer\GAL4elav.Switch.PO with RU486 feeding) partially rescues qvrEY04063/qvrEY04063 sleep phenotypes.

      Expressing qvrScer\UAS.cWa driven by Scer\GAL4Gad1.3.098 or Scer\GAL4VGAT.PF significantly restores sleep to 80-90% (respectively) of wild type levels in qvrEY04063/qvrEY04063 flies; rescued sleep is due to both lengthened sleep bout duration and increased bout number and sleep latency is returned to wild type levels.

      Expressing qvrScer\UAS.cWa driven by Scer\GAL4repo.PU or Scer\GAL4Gabat-PL00338 does not rescue sleep phenotypes (no significant changes in nighttime sleep, sleep bout duration or number, or sleep latency) in qvrEY04063/qvrEY04063 flies; when driven by Scer\GAL4repo.PU, there is a slight (significant) increase in day time sleep.

      (Chen et al., 2015)

      Expression of qvrScer\UAS.cWa under the control of Scer\GAL4qvr.PW completely rescues the reduced daily sleep seen in qvrEY04063 flies.

      (Wu et al., 2014)

      The amount of daily sleep returns to wild-type levels in qvrEY04063 mutant flies carrying both the Scer\GAL4qvr.PW driver and the qvrScer\UAS.cWa transgene.

      Pan-neural expression of qvrScer\UAS.cWa under the control of the Scer\GAL4elav-C155 driver fully rescues the qvrEY04063 mutant sleep phenotype.

      Expressing qvrScer\UAS.cWa in cholinergic neurons using Scer\GAL4Cha.7.4 results in strong rescue of the short-sleeping phenotype (but not the leg-shaking) of qvrEY04063 mutants.

      Scer\GAL4VGlut.PS- or Scer\GAL4ple.PF-driven expression of qvrScer\UAS.cWa results in weak or no rescue of the qvrEY04063 mutant sleep phenotype.

      The leg-shaking phenotype of qvrEY04063 mutants is rescued by Scer\GAL4elav-C155- or Scer\GAL4qvr.PW-driven expression of qvrScer\UAS.cWa.

      Scer\GAL4VGlut.PS driven expression of qvrScer\UAS.cWa rescues the qvrEY04063 mutant leg-shaking phenotype.

      Presynaptic expression of qvrScer\UAS.cWa driven by Scer\GAL4elav-C155 rescues the spontaneous miniature excitatory junctional potential (mEJP) frequency phenotype of qvrEY04063 mutants.

      Expression of qvrScer\UAS.cWa driven by either Scer\GAL4how-24B or Scer\GAL4Cha.7.4 fails to rescue the spontaneous miniature excitatory junctional potential (mEJP) frequency phenotype of qvrEY04063 mutants.

      Expression of qvrScer\UAS.cWa driven by Scer\GAL4how-24B rescues the Sh-dependent I[[A]] current kinetics and amplitude phenotypes of qvrEY04063 mutants.

      Expression of qvrScer\UAS.cWa driven by Scer\GAL4elav-C155 fails to rescue the Sh-dependent I[[A]] current kinetics and amplitude phenotypes of qvrEY04063 mutants.

      (Wu et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      qvrScer\UAS.cWa
      qvrUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wu
      Secondary FlyBase IDs
        References (4)