FlyBase Allele Report: Scer\GAL4[Gad1.3.098]

Expression is observed in GABAergic local interneurons which circumscribe the dorsal poles of the antennal lobes, and innervate all antennal glomeruli.

(Ng et al., 2002)

Marker for

GABAergic neuron

(Muthukumar et al., 2014, Nässel et al., 2008)

adult GABAergic neuron

(Wu et al., 2023)

adult antennal lobe local neuron

(Yu et al., 2004, Ng et al., 2002)

Reflects expression of

Gad1

(Muthukumar et al., 2014, Chen et al., 2012, Jefferis et al., 2004, Yu et al., 2004, Ng et al., 2002)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | third instar larval stage, with ChT^JF03028

(Hamid et al., 2021)

abnormal chemosensory behavior | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with ChT^JF03028

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal locomotor behavior | adult stage, with shi^1.UAS

(Chi et al., 2020)

abnormal neuroanatomy | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

bang sensitive, with Hsap\KCNT1^G288S.UAS

(Hussain et al., 2024)

bang sensitive, with Hsap\KCNT1^R398Q.UAS

(Hussain et al., 2024)

bang sensitive, with Hsap\KCNT1^R928C.UAS

(Hussain et al., 2024)

short lived | female, with sgg^UAS.cBa

(Trostnikov et al., 2019)

short lived | male, with sgg^UAS.cBa

(Trostnikov et al., 2019)

viable, with Hsap\KCNT1^G288S.UAS

(Hussain et al., 2024)

viable, with Hsap\KCNT1^R398Q.UAS

(Hussain et al., 2024)

viable, with Hsap\KCNT1^R928C.UAS

(Hussain et al., 2024)

viable, with Hsap\KCNT1^UAS.cHa

(Hussain et al., 2024)

Phenotype Manifest In

GABAergic neuron | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

Detailed Description

Statement

Reference

Ablation of GABAergic neurons through expression of hid in Scer\GAL4^Gad1.3.098 expressing neurons (limited to metamorphosis using Scer\GAL80^ts.αTub84B and shifting pupae to 25[o]) results in fewer GABAergic neurons in the medial-ventral region of the brain. Ablation of GABAergic neurons does not result in astrocyte loss.

(Muthukumar et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Hsap\SOD1^UAS.cWa/Scer\GAL4^Gad1.3.098 is a non-suppressor of abnormal neurophysiology | larval stage phenotype of Eaat1^hypo

(Peng et al., 2019)

Hsap\SOD1^UAS.cWa/Scer\GAL4^Gad1.3.098 is a non-suppressor of abnormal locomotor behavior | larval stage phenotype of Eaat1^hypo