Co-expression of Hsap\SOD1Scer\UAS.cWa enhances the toxicity of Scer\GAL4GMR.PU>Hsap\MAPTR406W.Scer\UAS in Drosophila compound eyes. The rough eye phenotype caused by Hsap\MAPTR406W.Scer\UAS-expression becomes more severe, and the ommatidia are more severely fused and irregular.
Co-expression of Hsap\SOD1Scer\UAS.cWa exacerbates the brain damage caused by the expression of Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS. The number of vacuoles is significantly increased in the double-transgenic flies compared with Hsap\MAPTR406W.Scer\UAS-expression alone.
park25 mutant flies expressing Hsap\SOD1Scer\UAS.cWa under the control of Scer\GAL4twi.PG do not show a difference in survival compared to park25 flies, up to 4 days of age. However, at 11 days of age only 10% of the park25 flies remain, compared to 80% of the park25 flies expressing Hsap\SOD1Scer\UAS.cWa under the control of Scer\GAL4twi.PG. None of the park25 flies sruvvie to 17 days of age, at which time point approximately 80% of Hsap\SOD1Scer\UAS.cWa-expressing flies are still alive.