FlyBase Allele Report: Dmel\Srpk79D[P10036]

General Information

Symbol

Dmel\Srpk79D^P10036

Species

D. melanogaster

Name

FlyBase ID

FBal0243482

Feature type

allele

Associated gene

Dmel\Srpk79D

Associated Insertion(s)

P{}Srpk79D^P10036

Carried in Construct

Also Known As

srpk79D^atc

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Johnson et al., 2009)

Mutagen

P-element activity

(Johnson et al., 2009)

Progenitor genotype

Associated Insertion(s)

P{}Srpk79D^P10036

Cytology

Description

A P-element insertion in one of the introns of srpk79D.

(Johnson et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon

(Johnson et al., 2009)

Detailed Description

Statement

Reference

No synaptic morphological defects are observed in the VA1v ORNs in Srpk79D^P10036/+ heterozygous adults.

(Mosca et al., 2017)

Electron micrographs reveal that srpk79D^P10036 mutant motor axons contain large, highly organised electron-dense structures that are never found in wild-type axons. Often, these electron dense structures appear strikingly similar to cytoplasmic protrusions known as T-bars that has been joined at their "bases" into a large T-bar aggregate.

(Johnson et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

Other

Statement

Reference

Lrp4^dalek, Srpk79D^P10036/Srpk79D[+] has abnormal neuroanatomy phenotype

(Mosca et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of adult olfactory receptor neuron phenotype of Lrp4^dalek

(Mosca et al., 2017)

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of synapse | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of presynaptic active zone | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

Other

Statement

Reference

Lrp4^dalek, Srpk79D^P10036/Srpk79D[+] has synapse | adult stage phenotype

(Mosca et al., 2017)

Lrp4^dalek, Srpk79D^P10036/Srpk79D[+] has adult olfactory receptor neuron phenotype

(Mosca et al., 2017)

Lrp4^dalek, Srpk79D^P10036/Srpk79D[+] has presynaptic active zone | adult stage phenotype

(Mosca et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Neither Lrp4^dalek/+ nor Srpk79D^P10036/+ single heterozygous adults display any defects in the synapse morphology in the VA1v olfactory receptor neurons but in Lrp4^dalek/+;Srpk79D^P10036/+ double heterozygotes the synapse number (assessed by counting active zone marker puncta) is significantly decreased compared to controls.

The reduced active zone number in the VA1v olfactory receptor neurons observed in Lrp4^dalek homozygous mutants is restored by expression of Srpk79D^P10036 under the control of Scer\GAL4^peb-GAL4 in the mutant background.

(Mosca et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Srpk79D^P10036

atc

(Johnson et al., 2009)

srpk79D^ATC

(Siebert et al., 2015)

srpk79D^P10036

srpk79D^atc

(DePew et al., 2024, Driller et al., 2019, Mosca et al., 2017, Johnson et al., 2009)

srpk^atc

(Mosca et al., 2017)

Name Synonyms

air traffic controller

(Johnson et al., 2009)

Secondary FlyBase IDs

References (5)

Report Sections

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