FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sin1UAS.Tag:FLAG
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General Information
Symbol
Dmel\Sin1UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0243554
Feature type
allele
Associated gene
Dmel\Sin1
Associated Insertion(s)
Carried in Construct
P{UAS-Sin1.Flag}
Key Links
Transgenic product class
wild_type
(Koike-Kumagai et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Koike-Kumagai et al., 2009)
Mutagen
in vitro construct
(Koike-Kumagai et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Sin1.Flag}
Cytology
Description

UASt regulatory sequences drive expression of the Sin1 coding region which is tagged with Tag:FLAG.

(Koike-Kumagai et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sin1
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1RNAi.UAS.cYa
      (Wu et al., 2013)
      modeled by Pink1B9
      (Wu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4ple.PF/Sin1UAS.Tag:FLAG is a suppressor of abnormal neuroanatomy | adult stage phenotype of Pink1B9

      (Wu et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is moderately suppressed by co-expression of Sin1Scer\UAS.T:Zzzz\FLAG.

      The mitochondrial aggregation phenotype seen in the dopaminergic neurons of Pink1B9 flies is moderately suppressed by co-expression of Sin1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ple.PF.

      The loss of dopaminergic neurons in the PPL1 cluster seen in Pink1B9 flies is suppressed by expression of Sin1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ple.PF.

      (Wu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Sin1UAS.Tag:FLAG/Scer\GAL4unspecified rescues Sin1e03756

      (Koike-Kumagai et al., 2009)

      Sin1UAS.Tag:FLAG/Scer\GAL4ppk.PG rescues Sin1e03756

      (Koike-Kumagai et al., 2009)
      Comments

      Class IV neuron-specific expression of Sin1Scer\UAS.T:Zzzz\FLAG largely rescues the dendritic phenotypes of single-cell Sin1e03756 class IV dendrite arborization neuron clones.

      Expression of Sin1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ppk.PG largely rescues the tiling defects seen in v'ada and vdaB neurons of Sin1e03756 mutants.

      (Koike-Kumagai et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sin1Scer\UAS.T:Zzzz\FLAG
      Sin1UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)