FlyBase Allele Report: Dmel\hid[w138]

General Information

Symbol

Dmel\hid^w138

Species

D. melanogaster

Name

FlyBase ID

FBal0243612

Feature type

allele

Associated gene

Dmel\hid

Associated Insertion(s)

Carried in Construct

Also Known As

hid¹³⁸

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tanaka-Matakatsu et al., 2009)

Progenitor genotype

Cytology

Description

312 bp deletion in the second exon of W, resulting in a frame shift and premature stop. The truncated 176 aa protein lacks the C-terminal hydrophobic region required for mitochondrial localisation, but retains the RHG domain and two MAKPK phosphorylation sites.

(Tanaka-Matakatsu et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:18,173,079..18,173,397 [-]

Comment:

Reported as a 312bp deletion in exon 2 removing the indicated sequences.

(Tanaka-Matakatsu et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death

(Tanaka-Matakatsu et al., 2009)

partially lethal - majority die

(Tanaka-Matakatsu et al., 2009)

visible

(Tanaka-Matakatsu et al., 2009)

Phenotype Manifest In

eye | somatic clone

(Tanaka-Matakatsu et al., 2009)

eye disc

(Tanaka-Matakatsu et al., 2009)

humeral bristle

(Tanaka-Matakatsu et al., 2009)

interommatidial bristle | increased number

(Tanaka-Matakatsu et al., 2009)

wing

(Tanaka-Matakatsu et al., 2009)

wing disc

(Tanaka-Matakatsu et al., 2009)

Detailed Description

Statement

Reference

W^w138 homozygous survivors have non-transparent wings, degenerated humeral bristles and additional interommatidial cells in the pupal retina.

W^w138 mutant clones occupy a slightly larger area in the adult eye compared to control wildtype clones.

Apoptosis induced by irradiation in eye and wing discs is significantly blocked in a W^w138 mutant background.

(Tanaka-Matakatsu et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hid^w138 is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of Rbf^15aΔ, Stam¹⁹

(Sheng et al., 2016)

hid^w138 is a suppressor of increased cell death | somatic clone phenotype of Axn^S044230, Rbf^15aΔ

(Zhang et al., 2014)

hid^w138 is a suppressor of increased cell death | somatic clone phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

hid^w138 is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Rbf^15aΔ, Stam¹⁹

(Sheng et al., 2016)

hid^w138 is a suppressor of eye disc | somatic clone phenotype of Axn^S044230, Rbf^15aΔ

(Zhang et al., 2014)

hid^w138 is a suppressor of eye | somatic clone phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

hid^w138 is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The high levels of apoptosis (detected by Caspase-3 staining) observed in Rbf^15aΔ;Stam¹⁹ double homozygous somatic in third instar larval eye disc is completely abolished when the clones are created in hid^w138 mutant background.

(Sheng et al., 2016)

Rbf^15aΔ; W^w138 double mutant clones occupy a dramatically increased area of the eye compared to Rbf^15aΔ single mutant clones. The morphology of the eye is relatively normal with occasional extra interommatidial bristles. No cell death or nuclear pyknosis is observed in eye disc clones.

(Tanaka-Matakatsu et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

hid⁰⁵⁰¹⁴

(Tanaka-Matakatsu et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

W^w138

hid¹³⁸

(Sheng et al., 2016, Zhang et al., 2014)

hid^w138

(Tanaka-Matakatsu et al., 2009)

w138

(Tanaka-Matakatsu et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close