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General Information
Symbol
Dmel\Stam19
Species
D. melanogaster
Name
FlyBase ID
FBal0319593
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T10860190A

Reported nucleotide change:

T?A

Amino acid change:

W269R | Stam-PA

Reported amino acid change:

W269R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W269R.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Somatic clones of Stam19/Stam19 cells in the third instar larval eye or wing disc display low levels of apoptosis (detected by Caspase-3 staining) and show abnormal localization of rho in endosomes, which often display both early and late markers.

Differentiation of the R8 photoreceptor in Stam19/Stam19 somatic clones in the third instar larval eye disc is normal but differentiation of other photoreceptors is slightly delayed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Somatic clones of Rbf15aΔ;Stam19 double homozygous cells display significantly higher levels of apoptosis in third instar larval wing and eye discs, even in clones posterior to the eye disc morphogenetic furrow, compared to clones homozygous for either Rbf15aΔ or Stam19 alone. In the adult eye, the double homozygous clones are very small and difficult to recover compared to each of the single homozygous clones.

The high levels of apoptosis (detected by Caspase-3 staining) observed in Rbf15aΔ;Stam19 double homozygous somatic in third instar larval eye disc is completely abolished when the clones are created in hidw138 mutant background.

The high levels of apoptosis (detected by Caspase-3 staining) observed in Rbf15aΔ;Stam19 double homozygous somatic clones in third instar larval eye disc is completely abolished when the clones are created in E2f1[i2]/E2f1[rM729] mutant background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Stam19
Name Synonyms
Secondary FlyBase IDs
    References (1)