FB2026_02 , released June 18, 2026
Allele: Dmel\gig64
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General Information
Symbol
Dmel\gig64
Species
D. melanogaster
Name
FlyBase ID
FBal0244514
Feature type
allele
Associated gene
Dmel\gig
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C?T.

    (Li et al., 2010)

    Amino acid replacement: ?432term.

    (Li et al., 2010)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:20,134,100..20,134,100 [+]
    Nucleotide change:

    C20134100T

    Reported nucleotide change:

    C?T

    Amino acid change:

    R432term | gig-PA; R432term | gig-PB

    Reported amino acid change:

    ?432term

    (Li et al., 2010)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        gig64 mutants exhibit large mutant patches (i.e discoloration and a rough appearance).

        (Li et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Rbf15aΔ, gig64 has increased cell death phenotype, suppressible by hid05014

        (Li et al., 2010)

        Rbf15aΔ, gig64 has increased cell death phenotype, suppressible by Dronc1

        (Li et al., 2010)

        Rbf15aΔ, gig64 has increased cell death phenotype, suppressible by E2f1i2

        (Li et al., 2010)

        Rbf15aΔ, gig64 has increased cell death phenotype, suppressible by S6kl-1

        (Li et al., 2010)
        Other
        Statement
        Reference

        Rbf15aΔ, gig64 has increased cell death phenotype

        (Li et al., 2010)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        Rbf15aΔ, gig64 has eye disc posterior to the morphogenetic furrow phenotype, suppressible by Dronc1

        (Li et al., 2010)

        Rbf15aΔ, gig64 has eye | somatic clone phenotype, suppressible by E2f1i2

        (Li et al., 2010)

        Rbf15aΔ, gig64 has eye | somatic clone phenotype, suppressible by S6kl-1

        (Li et al., 2010)
        Other
        Statement
        Reference

        Rbf15aΔ, gig64 has wing disc phenotype

        (Li et al., 2010)

        Rbf15aΔ, gig64 has eye | somatic clone phenotype

        (Li et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        gig64/Rbf15aΔ mutant eye clones are smaller than gig64 mutant eye clones. Adult eyes with gig64/Rbf15aΔ double mutant cones are smaller and display a rough appearance, compared to wild-type eyes. This correlates with an increase in apoptosis in both anterior and posterior (to the morphogenic furrow) clones in double mutant eye discs. This synergistic induction of cell death is also seen in the wing disc.

        The presence of a W05014 background significantly decreases gig192/Rbf15aΔ induced cell death. Some cell death is still observed, particularly in the anterior of the eye disc.

        The presence of a Nc1 background significantly decreases gig192/Rbf15aΔ induced cell death in the posterior (the differentiating part of the eye disc). However Nc1 has little effect on cell death of gig192/Rbf15aΔ clones in the anterior, the proliferating part of the eye disc. These triple mutants exhibit an increase in mutant tissue in the eye as well as their overall size.

        The presence of an E2fi2 background significantly decreases gig192/Rbf15aΔ induced cell death in the eye. In addition, much larger gig192/Rbf15aΔ double mutant clones are observed in adult eyes.

        The presence of a S6kl-1 background significantly decreases gig192/Rbf15aΔ induced cell death in the eye. In addition, much larger gig192/Rbf15aΔ double mutant clones are observed in adult eyes.

        (Li et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        gig64
        (Li et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)