FlyBase Allele Report: Dmel\Dronc[1]

General Information

Symbol

Dmel\Dronc¹

Species

D. melanogaster

Name

FlyBase ID

FBal0243349

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Du, 2010.4.23)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(Du, 2010.4.23)

Amino acid replacement: R195term.

(Du, 2010.4.23)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:9,969,979..9,969,979 [+]

Nucleotide change:

C9969979T

Reported nucleotide change:

C?T

Amino acid change:

R195term | Dronc-PA

Reported amino acid change:

R195term

(Du, 2010.4.23)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Dronc¹ is a non-enhancer of increased cell number | third instar larval stage | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Suppressor of

Statement

Reference

Dronc¹ is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig⁶⁴

(Li et al., 2010)

Dronc¹ is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig¹⁹²

(Li et al., 2010)

Dronc¹ is a suppressor of increased cell death | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Dronc¹ is a non-enhancer of eye | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Dronc¹ is a non-enhancer of interommatidial bristle | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Dronc¹ is a non-enhancer of photoreceptor cell R8 | third instar larval stage | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Dronc¹ is a non-enhancer of eye | somatic clone phenotype of Rbf^15aΔ, rno^K

(Steele et al., 2009)

Suppressor of

Statement

Reference

Dronc¹ is a suppressor of eye disc posterior to the morphogenetic furrow phenotype of Rbf^15aΔ, gig⁶⁴

(Li et al., 2010)

Dronc¹ is a suppressor of eye disc posterior to the morphogenetic furrow phenotype of Rbf^15aΔ, gig¹⁹²

(Li et al., 2010)

Dronc¹ is a suppressor of eye disc | somatic clone phenotype of Rbf^15aΔ, rno³

(Steele et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of a Nc¹ background significantly decreases gig⁶⁴/Rbf^15aΔ induced cell death in the posterior (the differentiating part of the eye disc). However Nc¹ has little effect on cell death of gig⁶⁴/Rbf^15aΔ clones in the anterior, the proliferating part of the eye disc. These triple mutants exhibit an increase in mutant tissue in the eye as well as their overall size.

The presence of a Nc¹ background significantly decreases gig¹⁹²/Rbf^15aΔ induced cell death in the posterior (the differentiating part of the eye disc). However Nc¹ has little effect on cell death of gig¹⁹²/Rbf^15aΔ clones in the anterior, the proliferating part of the eye disc. These triple mutants exhibit an increase in mutant tissue in the eye as well as their overall size.

(Li et al., 2010)

Rbf^15aΔ; rno³ mutant clones carrying an additional mutation in Nc¹ show significantly decreased levels of apoptosis.

The shiny-eye phenotype observed in rno^K, Rbf^15aΔ mutant somatic clones is not enhanced by Nc¹.

The shiny-eye phenotype, lack of pupal and adult bristle cells, and multiple photoreceptor-R8 cells seen in ommatidial clusters arising from rno³, Rbf^15aΔ mutant eye clones is not enhanced by Nc¹.

(Steele et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dronc¹

Dronc^O1

(Baillon et al., 2018)

Nc¹

(Li et al., 2010)

dronc⁰¹

(Tanaka-Matakatsu et al., 2009)

Name Synonyms

Dronc01

(Du, 2010.4.23)

Secondary FlyBase IDs

References (5)

Report Sections

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