FlyBase Allele Report: Dmel\RhoL[10-161]

General Information

Symbol

Dmel\RhoL^10-161

Species

D. melanogaster

Name

FlyBase ID

FBal0245175

Feature type

allele

Associated gene

Dmel\RhoL

Associated Insertion(s)

P{GawB}RhoL^10-161

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Siekhaus et al., 2010)

Mutagen

P-element activity

(Siekhaus et al., 2010)

Progenitor genotype

Associated Insertion(s)

P{GawB}RhoL^10-161

Cytology

Description

Insertion of P{GawB} in the promoter of RhoL, 5' upstream of the transcript start.

(Siekhaus et al., 2010)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Siekhaus et al., 2010)

Phenotype Manifest In

hemocyte | embryonic stage

(Siekhaus et al., 2010)

Detailed Description

Statement

Reference

In RhoL^10-161 mutant embryos, an average of 20 haemocytes migrate into the tail region of the embryo, compared with 34 in RhoL^10-161/+ embryos.

(Siekhaus et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

RhoL^10-161 has hemocyte | embryonic stage phenotype, non-enhanceable by PDZ-GEF^Δ1

(Siekhaus et al., 2010)

Suppressed by

Statement

Reference

RhoL^10-161 has hemocyte | embryonic stage phenotype, suppressible by shg^k03401

(Siekhaus et al., 2010)

Suppressor of

Statement

Reference

RhoL^10-161 is a suppressor of hemocyte | embryonic stage phenotype of Rap1^V12.cHa.UAS

(Siekhaus et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

RhoL^10-161;shg^k03401 double homozygous mutant embryos display the normal number of haemocytes migrating into the tail region of the embryo.

The number of haemocytes that migrate into the tail region is reduced in Gef26^Δ1, RhoL^10-161 double mutant embryos, comparable to the reduced number observed in RhoL^10-161 mutants.

Hemocyte clustering observed in embryos expressing R^{V12.cHa.Scer\UAS} under the control of Scer\GAL4^srp.Hemo is abolished in the presence of RhoL^10-161.

(Siekhaus et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

RhoL^10-161

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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