FlyBase Allele Report: Dmel\neur[NIG.11988R]

General Information

Symbol

Dmel\neur^NIG.11988R

Species

D. melanogaster

Name

FlyBase ID

FBal0246153

Feature type

allele

Associated gene

Dmel\neur

Associated Insertion(s)

Carried in Construct

P{NIG.11988R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Hamel et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Hamel et al., 2010)

Mutagen

in vitro construct

(Hamel et al., 2010)

Progenitor genotype

Carried in construct

P{NIG.11988R}

Cytology

Description

UASt regulatory sequences drive expression of a neur RNAi construct.

(Hamel et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-11988R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^ato.3.6

(Langen et al., 2013)

visible, with Scer\GAL4^pnr-MD237

(Hamel et al., 2010)

Phenotype Manifest In

chaeta | increased number, with Scer\GAL4^pnr-MD237

(Hamel et al., 2010)

lobula columnar neuron LC14, with Scer\GAL4^ato.3.6

(Langen et al., 2013)

medulla, with Scer\GAL4^ato.3.6

(Langen et al., 2013)

Detailed Description

Statement

Reference

Expression of neur^NIG.11988R under the control of Scer\GAL4^ato.3.6 results in clustering of dorsal cluster neuron axons. There is a significant increase in the number of axons targeting the medulla compared to wild type.

(Langen et al., 2013)

Expression of neur^NIG.11988R under the control of Scer\GAL4^pnr-MD237 post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80^ts.αTub84B which is present in the stock) results in a strong neurogenic phenotype with an excess of bristles.

(Hamel et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, neur^NIG.11988R has visible phenotype, suppressible by α4GT1^GS2078, Scer\GAL4^pnr-MD237

(Hamel et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, neur^NIG.11988R has chaeta | increased number phenotype, suppressible by α4GT1^GS2078, Scer\GAL4^pnr-MD237

(Hamel et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The excess bristles phenotype caused by expression of neur^NIG.11988R under the control of Scer\GAL4^pnr-MD237 post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80^ts.αTub84B which is present in the stock) is suppressed by co-expression of α4GT1^GS2078.

(Hamel et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

11988R-1

P{NIG.11988R}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

neur^NIG.11988R

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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