FB2026_02 , released June 18, 2026
Allele: Dmel\AMPKαUAS.cBa
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General Information
Symbol
Dmel\AMPKαUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Bland
FlyBase ID
FBal0246371
Feature type
allele
Associated gene
Dmel\AMPKα
Associated Insertion(s)
Carried in Construct
P{UAS-AMPKα.B}
Key Links
Transgenic product class
cDNA
(Bland et al., 2010)
wild_type
(Bland et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Bland et al., 2010)
wild_type
(Bland et al., 2010)
Mutagen
in vitro construct
(Bland et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-AMPKα.B}
Cytology
Description

UASt regulatory sequences drive expression of the full length AMPKα GH12596 cDNA clone.

(Bland et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
AMPKα
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      AMPKαUAS.cBa/Scer\GAL4unspecified rescues AMPKαΔ39

      (Bland et al., 2010)
      Partially rescues

      AMPKαUAS.cBa/Scer\GAL4Mef2.PR partially rescues AMPKαΔ39

      (Bland et al., 2010)

      AMPKαUAS.cBa/Scer\GAL4how-24B partially rescues AMPKαΔ39

      (Bland et al., 2010)
      Fails to rescue

      AMPKαUAS.cBa/Scer\GAL4Mhc.PW fails to rescue AMPKαΔ39

      (Bland et al., 2010)
      Comments

      Ubiquitous expression of SNF1AScer\UAS.cBa rescues the lethality of SNF1AΔ39 mutants.

      The reduced gut function seen in SNF1AΔ39 mutant larvae is rescued by expression of SNF1AScer\UAS.cBa under the control of either Scer\GAL4Mef2.PR or Scer\GAL4how-24B, but is not rescued by expression of SNF1AScer\UAS.cBa under the control of Scer\GAL4Mhc.PW.

      The reduced triglyceride content of SNF1AΔ39 mutant larvae is rescued by expression of SNF1AScer\UAS.cBa under the control of Scer\GAL4how-24B.

      Expression of SNF1AScer\UAS.cBa under the control of Scer\GAL4how-24B rescues the early pupal lethality of SNF1AΔ39 animals, permitting the completion of metamorphosis in 49% animals. Most of the rescued animals do not eclose, but those that do eclose survive for up to 4 days as adults.

      Expression of SNF1AScer\UAS.cBa under the control of Scer\GAL4Mef2.PR rescues pupal lethality, but not eclosion, in 9% of SNF1AΔ39 animals.

      (Bland et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      AMPKαScer\UAS.cBa
      AMPKαUAS.cBa
      SNF1AScer\UAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Bland
      Secondary FlyBase IDs
        References (1)