FB2026_03 , released September 17, 2026
Allele: Dmel\soloZ2-3534
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General Information
Symbol
Dmel\soloZ2-3534
Species
D. melanogaster
Name
FlyBase ID
FBal0246480
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Amino acid replacement: L1010term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

T15071976R

Amino acid change:

L1010term | solo-PA; L1010term | solo-PB

Reported amino acid change:

L1010term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Nucleotide change unspecified, T to A or T to G.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

soloZ2-3534/Df(2L)A267 females show 60.0% X chromosome nondisjunction. Crossing over on the X chromosome is substantially and uniformly reduced in three euchromatic intervals and more moderately reduced in the interval encompassing the X centromere. Sister chromatid exchange on the X chromosome is increased compared to controls.

solo7/soloZ2-3534 females show chromosome 2 nondisjunction.

Both homologous centromere pairing and centromere clustering appear to be disrupted by early-mid pachytene of meiosis I in soloZ2-3534/Df(2L)A267 females. Sister chromatid cohesion appears intact at early-mid pachytene, but by late pachytene, some sister centromere pairs appear to have separated prematurely in more than half of the mutant oocyte nuclei. Synaptonemal complex morphology is abnormal, with fragmentation and degeneration of the lateral elements and central regions of the synaptonemal complex at all stages of pachytene. The formation of meiotic double strand breaks is not impaired in the mutant germaria, but there is a transient delay in repair of these breaks compared to wild type.

soloZ2-3534/Df(2L)A267 males show a high frequency (58.0%) of sex chromosome nondisjunction in meiosis.

soloZ2-3534/soloZ2-0198 males show a high frequency (54.1%) of sex chromosome nondisjunction in meiosis.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Crossover frequency in the X euchromatin (pn-f interval) is reduced 65-fold in soloZ2-3534 ordZ5736/soloZ2-0198 ord5 females compared to doubly heterozygous sibling controls. This reduction is intermediate in value between those of ord or solo single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
vassolo-Z2-3534
Name Synonyms
Secondary FlyBase IDs
    References (2)