FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cal1UAS.EGFP
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General Information
Symbol
Dmel\cal1UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0247227
Feature type
allele
Associated gene
Dmel\cal1
Associated Insertion(s)
Carried in Construct
P{UAS-cal1.EGFP}
Key Links
Transgenic product class
wild_type
(Schittenhelm et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schittenhelm et al., 2010)
Mutagen
in vitro construct
(Schittenhelm et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-cal1.EGFP}
Cytology
Description

UAS regulatory sequences drive expression of full length cal1 (amino acid residues 1-979) which are tagged with EGFP.

(Schittenhelm et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cal1
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing cal1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4prd.RG1 often show mitotic abnormalities during stage 16.

      (Schittenhelm et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous co-expression of cal1Scer\UAS.T:Avic\GFP-EGFP and cidScer\UAS.cJa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in mitotic defects in embryos at mitosis 16.

      Simultaneous co-expression of cal1Scer\UAS.T:Avic\GFP-EGFP, cidScer\UAS.cJa and Cenp-CScer\UAS.cHa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in strong mitotic defects in embryos at mitosis 16. The most prominent defects are abnormal anaphase and telophase figures with chromatin bridges containing lagging centromeres.

      (Schittenhelm et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      cal1UAS.EGFP/Scer\GAL4sca-537.4 rescues cal1unspecified

      (Schittenhelm et al., 2010)
      Comments

      Expression of cal1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4sca-537.4 rescues normal cell proliferation in cal1unspecified embryos.

      (Schittenhelm et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cal1Scer\UAS.T:Avic\GFP-EGFP
      cal1UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)