FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cenp-CUAS.cHa
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General Information
Symbol
Dmel\Cenp-CUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Heeger
FlyBase ID
FBal0191626
Feature type
allele
Associated gene
Dmel\Cenp-C
Associated Insertion(s)
Carried in Construct
P{UAS-Cenp-C.H}
Also Known As
UAS-Cenp-C
Key Links
Transgenic product class
wild_type
(Heeger et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Heeger et al., 2005)
Mutagen
in vitro construct
(Heeger et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Cenp-C.H}
Cytology
Description

UAS regulatory sequences drive expression of full length Cenp-C.

(Heeger et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Cenp-C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cenp-CScer\UAS.cHa under the control of Scer\GAL4GMR.PF has no effect on the eye.

      (Heeger et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous co-expression of cal1Scer\UAS.T:Avic\GFP-EGFP, cidScer\UAS.cJa and Cenp-CScer\UAS.cHa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in strong mitotic defects in embryos at mitosis 16. The most prominent defects are abnormal anaphase and telophase figures with chromatin bridges containing lagging centromeres.

      Embryos simultaneously co-expressing cal1Scer\UAS.cSa, cidScer\UAS.cJa and Cenp-CScer\UAS.cHa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 already show mitotic defects during mitosis 15. Chromosome congression into a metaphase plate is always slower than normal and metaphase is usually prolonged. Chromosome segregation is abnormal in approximately half of anaphases, with the defect usually consisting of lagging centromeres. The distance between sister kinetochores in metaphase plates is scattered over a larger range in the mutant embryos compared to the range seen in controls.

      (Schittenhelm et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cenp-CScer\UAS.cHa
      Cenp-CUAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Heeger
      (Heeger et al., 2005)
      Secondary FlyBase IDs
        References (2)