FlyBase Allele Report: Dmel\sqh[HMS00437]

General Information

Symbol

Dmel\sqh^HMS00437

Species

D. melanogaster

Name

FlyBase ID

FBal0248195

Feature type

allele

Associated gene

Dmel\sqh

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00437}

Also Known As

sqh RNAi, UAS-sqh-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00437}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00437

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

retina, with Scer\GAL4^GMR.PU

(Nie et al., 2014)

retina | somatic clone, with Scer\GAL4^GMR.PU

(Nie et al., 2014)

Detailed Description

Statement

Reference

Expression of sqh^HMS00437 under the control of Scer\GAL4^GMR.PU results in fused rhabdomeres.

Flip out clones expressing sqh^HMS00437 under the control of Scer\GAL4^GMR.PU have a reduced distance between the apical membranes of rhabdomeres R2 and R4 (width of the retinal lumen) compared to controls.

(Nie et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sqh^HMS00437, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

sqh^HMS00437, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

sqh^HMS00437/Scer\GAL4^GMR.PU is an enhancer of retina phenotype of eys¹, prom[+]/prom¹

(Nie et al., 2014)

Suppressor of

Statement

Reference

sqh^HMS00437, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

sqh^HMS00437, Scer\GAL4^repo.PU is a suppressor of larval brain neuropil glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Scer\GAL4^Cg.PA/sqh^HMS00437 is a suppressor of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Scer\GAL4^Cg.PA/sqh^HMS00437 is a suppressor of endoplasmic reticulum | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Scer\GAL4^Cg.PA/sqh^HMS00437 is a suppressor of nucleus | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of sqh^HMS00437 under the control of Scer\GAL4^GMR.PU enhances the rhabdomere fusion seen in eys¹ prom¹ double heterozygotes.

(Nie et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32439

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00437}attP2

NIG-Fly

HMS00437

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00437}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sqh³²⁴³⁹

(Ermanoska et al., 2025)

sqh^HMS00437

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close