FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hhUAS.cUa
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General Information
Symbol
Dmel\hhUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0248862
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
P{UAS-hh.Unspecified}
Also Known As
UAS-hh
Key Links
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-hh.Unspecified}
Cytology
Description

UAS regulatory sequences drive expression of hh.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
hh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Under ad libitum nutrition, the adulthood-only expression of hhUAS.cUa under the control of Scer\GAL4bab1-Pgal4-2 (and Gal80[ts] for temporal control of expression) leads to excessive or disorganized basal stalk cells, mis-shaped follicle cells and/or multilayering of the follicular epithelium, as compared to controls. Under starvation, this expression leads to a significant increase in mitotic index of the follicular epithelium, but leads to a less severe multilayering phenotype, as compared to controls.

      (Çiçek et al., 2016)

      Compared to controls unresponsive to a 38[o]C probe (without pre-exposure to UV), early third instar larvae with expression of hhScer\UAS.cUa driven by Scer\GAL4ppk.1.9 (but not Scer\GAL4A58 or Scer\GAL4Myo31DF-NP0001) show significant withdrawal responses (genetic allodynia).

      (Im et al., 2015)

      In wild type third instar larvae, two dorsal tracheal branches fuse to give rise to two terminal cells with multiple branches; a significantly increased percentage of Scer\GAL4btl.PU>hhScer\UAS.cUa mutant terminal branches have excess (>2) terminal cells.

      (Kim et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of dispGD2813 significantly suppresses the withdrawal responses to a 38[o]C probe (without pre-exposure to UV) seen in early third instar larvae with hhScer\UAS.cUa over-expressed by Scer\GAL4ppk.1.9.

      (Im et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hhScer\UAS.cUa
      hhUAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (16)