FlyBase Allele Report: Dmel\Su(Tpl)[HMS00277]

General Information

Symbol

Dmel\Su(Tpl)^HMS00277

Species

D. melanogaster

Name

FlyBase ID

FBal0257176

Feature type

allele

Associated gene

Dmel\Su(Tpl)

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00277}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00277}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00277

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M.UAS.Tag:FLAG}

(Azpurua et al., 2021)

modeled by Hsap\TARDBP^UAS.cEa

(Chung et al., 2018)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^48.UAS

(Chung et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Su(Tpl)^HMS00277 under the control of Scer\GAL4^pnt-14-94 leads to a severe decrease in the number of type II neuroblasts per third instar larval brain lobe, which also exhibit decreased progeny as compared to controls; expression under the control of Scer\GAL4^insc-Mz1407 also leads to a severe decrease in the number of type II neuroblasts per third instar larval brain lobe, which exhibit normal cortical polarity, as compared to controls; expression under the control of Scer\GAL4^ase.neuro, but not Scer\GAL4^pnt-14-94, also leads to a small but significant decrease in the number of type I neuroblasts, as compared to controls.

(Liu et al., 2017)

Embryos from mothers expressing Su(Tpl)^HMS00277 under the control of Scer\GAL4^{VP16.mat.αTub67C} show posterior-specific loss of cells in embryos prior to gastrulation.

(Dahlberg et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^pnt-14-94, Su(Tpl)^HMS00277 has decreased cell number | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Scer\GAL4^pnt-14-94, Su(Tpl)^HMS00277 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Snr1^HMS00363

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor of abnormal size | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Snr1^HMS00363

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Snr1^HMS00363

(Liu et al., 2017)

Su(Tpl)^HMS00277, Scer\GAL4^insc-Mz1407 is a suppressor | partially of increased cell number | third instar larval stage phenotype of E(spl)mγ-HLH^UAS.cLb, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

Su(Tpl)^HMS00277, Scer\GAL4^insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of E(spl)mγ-HLH^UAS.cLb, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^pnt-14-94, Su(Tpl)^HMS00277 has type II neuroblast | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Scer\GAL4^pnt-14-94, Su(Tpl)^HMS00277 has larval brain | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^drm.7.1/Su(Tpl)^HMS00277 is an enhancer of terminal tracheal cell | larval stage phenotype of Scer\GAL4^drm.7.1, trc^GL01127

(Hudson et al., 2023)

Suppressor of

Statement

Reference

Su(Tpl)^HMS00277/Scer\GAL4^pnt-14-94 is a suppressor of larval brain | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(H)^VP16.UAS

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor of larval brain | third instar larval stage phenotype of Scer\GAL4^pnt-14-94, Su(H)^VP16.UAS

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor | partially of type II neuroblast | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Snr1^HMS00363

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor | partially of larval brain | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Snr1^HMS00363

(Liu et al., 2017)

Su(Tpl)^HMS00277, Scer\GAL4^insc-Mz1407 is a suppressor | partially of neuroblast | third instar larval stage phenotype of E(spl)mγ-HLH^UAS.cLb, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

Su(Tpl)^HMS00277, Scer\GAL4^insc-Mz1407 is a suppressor | partially of larval brain | third instar larval stage phenotype of E(spl)mγ-HLH^UAS.cLb, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

Su(Tpl)^HMS00277/Scer\GAL4^pnt-14-94 is a suppressor of neuroblast | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(H)^VP16.UAS

(Liu et al., 2017)

Scer\GAL4^insc-Mz1407/Su(Tpl)^HMS00277 is a suppressor of neuroblast | third instar larval stage phenotype of Scer\GAL4^pnt-14-94, Su(H)^VP16.UAS

(Liu et al., 2017)

Other

Statement

Reference

Scer\GAL4^drm.7.1, Su(Tpl)^HMS00277, trc^GL01127 has embryonic/larval dorsal tracheal branch | larval stage phenotype

(Hudson et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Su(Tpl)^HMS00277 strongly or fully suppresses the increased number of neuroblasts in third instar larval brains resulting from the Scer\GAL4^insc-Mz1407-driven expression of E(spl)mγ-HLH^Scer\UAS.cLb (strongly), Snr1^HMS00363 (strongly), or Su(H)^{Scer\UAS.T:Hsim\VP16} (fully); the co-expression of Su(Tpl)^HMS00277 suppresses the same phenotype in individuals expressing Su(H)^{Scer\UAS.T:Hsim\VP16} under the control of Scer\GAL4^pnt-14-94.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

The decreased number of type II neuroblasts in third instar larval brains expressing Su(Tpl)^HMS00277 under the control of Scer\GAL4^insc-Mz1407 is not suppressed by the co-expression of BacA\p35^Scer\UAS.cHa.

(Liu et al., 2017)

Complementation and Rescue Data

Rescued by

Su(Tpl)^HMS00277 is rescued by Su(Tpl)^{UAS.SR.Tag:MYC}/Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Comments

The decreased number of type II neuroblasts per third instar larval brain lobe resulting from the expression of Su(Tpl)^HMS00277 under the control of Scer\GAL4^pnt-14-94 is rescued by the co-expression of Su(Tpl)^{Scer\UAS.SR.T:Hsap\MYC}.

(Liu et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33399

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00277}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Su(Tpl)^HMS00277

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close