FlyBase Allele Report: Dmel\Atg101[HMS01349]

General Information

Symbol

Dmel\Atg101^HMS01349

Species

D. melanogaster

Name

FlyBase ID

FBal0257942

Feature type

allele

Associated gene

Dmel\Atg101

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01349}

Also Known As

HMS01349

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01349}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01349

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

ameliorates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

decreased cell death | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

Phenotype Manifest In

embryonic/larval midgut | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

gastric caecum | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

Detailed Description

Statement

Reference

Expression of Atg101^HMS01349 under the control of Scer\GAL4^{Myo31DF-NP0001} results in significantly delayed midgut degradation after pupariation, with increased size of the midgut and gastric caeca 4 hrs after puparium formation, and decreased autophagy 2 hrs after puparium formation, as compared to controls.

(Xu et al., 2015)

Expression of Atg101^HMS01349 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} does not result in melanisation of the fat body.

(Zang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Atg101^HMS01349, Scer\GAL4^elav.PU is a suppressor of abnormal heat stress response | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU