FlyBase Allele Report: Dmel\TER94[UAS.cCa]

General Information

Symbol

Dmel\TER94^UAS.cCa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Chang

FlyBase ID

FBal0258032

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

Carried in Construct

P{UAS-TER94.C}

Also Known As

UAS-TER94^wt

Key Links

Transgenic product class

wild_type

(Chang et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Chang et al., 2011)

Mutagen

in vitro construct

(Chang et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-TER94.C}

Cytology

Description

UAS regulatory sequences drive expression of wild-type TER94.

(Chang et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TER94

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 2

modeled by park²⁵

(Zhang et al., 2017)

ameliorates Parkinson's disease 6

modeled by Pink1⁵

(Zhang et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Chang et al., 2011)

flightless, with Scer\GAL4^Mhc.PW

(Chang et al., 2011)

Phenotype Manifest In

eye photoreceptor cell, with Scer\GAL4^GMR.PF, TER94^A229E.UAS

(Chang et al., 2011)

eye photoreceptor cell, with Scer\GAL4^GMR.PF, TER94^R152H.UAS

(Chang et al., 2011)

eye photoreceptor cell, with Scer\GAL4^GMR.PF, TER94^R188Q.UAS

(Chang et al., 2011)

Detailed Description

Statement

Reference

Expression of TER94^Scer\UAS.cCa under the control of Scer\GAL4^Hand.PU does not cause any obvious morphological defects in the adult heart. Expression under the Scer\GAL4^how-24B does not disrupt either the cardioblasts organization or the intersegmental somatic muscle pattern in stage 16 embryos.

(Viswanathan et al., 2016)

Expression of TER94^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF has no effect on eye morphology.

(Liang et al., 2014)

Muscle fibers develop normally in embryos overexpressing TER94^Scer\UAS.cCa under the control of Scer\GAL4^how-24B.

Flies expressing TER94^Scer\UAS.cCa under the control of Scer\GAL4^Mhc.PW show impaired flight.

Flies expressing TER94^Scer\UAS.cCa in photoreceptor cells under the control of Scer\GAL4^GMR.PF do not show any eye defects.

Retinas of flies expressing TER94^Scer\UAS.cCa under the control of Scer\GAL4^ninaE.PT show normal rhabdomere organisation.

Co-expression of TER94^Scer\UAS.cCa and TER94^{R152H.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in rough eye and photoreceptor cell abnormalities.

Co-expression of TER94^Scer\UAS.cCa and TER94^{R188Q.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in rough eye and photoreceptor cell abnormalities.

Co-expression of TER94^Scer\UAS.cCa and TER94^{A229E.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in rough eye and photoreceptor cell abnormalities.

Animals co-expressing TER94^K2A.Scer\UAS and TER94^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF survive.

(Chang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

TER94^UAS.cCa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Der-1^UAS.cLa, Scer\GAL4^GMR.PF

(Liang et al., 2014)

Other

Statement

Reference

Der-1^SH1964/l(2)SH1964[+], Scer\GAL4^GMR.PF, TER94^UAS.cCa has visible phenotype

(Liang et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

TER94^UAS.cCa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Der-1^UAS.cLa, Scer\GAL4^GMR.PF

(Liang et al., 2014)

Other

Statement

Reference

Der-1^SH1964/l(2)SH1964[+], Scer\GAL4^GMR.PF, TER94^UAS.cCa has eye phenotype

(Liang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of TER94^Scer\UAS.cCa and Der-1^Scer\UAS.cLa results in a reduction in ATPase activity compared to controls.

Expression of TER94^Scer\UAS.cCa suppresses the eye phenotypes seen when Der-1^Scer\UAS.cLa is expressed under the control of Scer\GAL4^GMR.PF.

Expression of TER94^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF in a heterozygous Der-1^SH1964 mutant background results in a rough eye phenotype.

(Liang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

TER94^Scer\UAS.cCa

TER94^UAS.cCa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Chang

Secondary FlyBase IDs

References (6)

Report Sections

Open Close