FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ebd1Df5
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General Information
Symbol
Dmel\ebd1Df5
Species
D. melanogaster
Name
FlyBase ID
FBal0258661
Feature type
allele
Associated gene
Dmel\ebd1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Benchabane et al., 2011)
Progenitor genotype
P{EPgy2}ebd1EY01876
(Benchabane et al., 2011)
Caused by aberration
Df(3L)5
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a 2821bp deletion from -1922 to +899 relative to the ebd1 transcription start site, which removes part of ebd1 and part of CG3344.

(Benchabane et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:684,646..687,467 [-]
Comment:

2821 bp deletion resulting from the imprecise excision of P{EPgy2}ebd1EY01876 which removes part of ebd1 and part of hiro. Extends from -1922 to +899 relative to the ebd1 transcription start site. 3L:685545 (R5) was used as the transcription start site for the mapping.

(Benchabane et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In adult midguts bearing ebd1Df5 mutant MARCM clones, an abnormally large number of progenitor cells (due to excessive mitotic activity of the cells) is found in the vicinity of the mutant clones.

      (Tian et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      ebd1Df5/ebd1240, ebd2136/ebd2[+] has increased cell number | adult stage phenotype

      (Tian et al., 2017)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ebd1Df5/ebd1240 is a suppressor of retina phenotype of ApcQ8

      (Benchabane et al., 2011)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adult ebd1240/ebd1Df5,ebd2136 mutants show significant increase in the number of progenitor cells (intestinal stem cells and enteroblasts) in the midgut and unlike in controls frequently display chains or clusters of progenitor cells, the penetrance of this latter phenotype is increased further in ebd1Df5,ebd2136/ebd1240,ebd2136 double mutants.

      (Tian et al., 2017)

      ebd1240/ebd1Df5 suppresses the apoptosis of photoreceptor cells which is seen in ApcQ8 homozygotes, such that the rescued photoreceptors are wild type in length.

      (Benchabane et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ebd15
      (Tian et al., 2017)
      ebd1Df5
      Name Synonyms
      Secondary FlyBase IDs
        References (2)