FlyBase Allele Report: Dmel\CYLD[mr4]

General Information

Symbol

Dmel\CYLD^mr4

Species

D. melanogaster

Name

FlyBase ID

FBal0260899

Feature type

allele

Associated gene

Dmel\CYLD

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

recombination

Nature of the Allele

Allele class

Mutagen

recombination

(Xue et al., 2007)

Progenitor genotype

P{PZ}nmd⁰⁸⁷⁷⁴

(Xue et al., 2007)

Caused by aberration

Df(2L)CYLD^mr4

Cytology

Description

5kb deletion generated by male recombination. The deletion removes the entire upstream region and the first 57 amino acid residues of CYLD, the entire CG13138 transcription unit and the coding region of nmd.

(Xue et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | recessive

(Xue et al., 2007)

fertile

(Xue et al., 2007)

short lived | recessive

(Xue et al., 2007)

viable

(Xue et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

CYLD^mr4 mutant adults (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd) are viable and fertile without any obvious morphological defects. However, CYLD^mr4 homozygotes show a significant reduction in both median and maximal lifespan compared to wild-type or heterozygous flies. CYLD^mr4 homozygotes show significantly reduced survival after exposure to paraquat compared to wild-type or heterozygous flies.

(Xue et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CYLD^mr4 has short lived | recessive phenotype, suppressible by bsk^UAS.cBa/Scer\GAL4^Tub.PU

(Xue et al., 2007)

CYLD^mr4 has abnormal oxidative stress response | recessive phenotype, suppressible by bsk^UAS.cBa/Scer\GAL4^Tub.PU

(Xue et al., 2007)

Suppressor of

Statement

Reference

CYLD^mr4/CYLD[+] is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

CYLD^mr4/CYLD^mr4 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

NOT Suppressor of

Statement

Reference

CYLD^mr4/CYLD^mr4 is a non-suppressor of visible phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

CYLD^mr4/CYLD[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

CYLD^mr4/CYLD^mr4 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

NOT Suppressor of

Statement

Reference

CYLD^mr4/CYLD^mr4 is a non-suppressor of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of bsk^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU rescues both the shortened lifespan increased sensitivity to paraquat which is seen in CYLD^mr4 mutant adults (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd).

The small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF is partially suppressed by one copy of CYLD^mr4 (animals heterozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd) and is almost completely suppressed by homozygosity for CYLD^mr4 (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107}).

Homozygosity for CYLD^mr4 (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd) has no effect on the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

(Xue et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CYLD^mr4 is rescued by CYLD^UAS.cXa/Scer\GAL4^Tub.PU

(Xue et al., 2007)

CYLD^mr4 is rescued by CYLD^UAS.cXa/Scer\GAL4^GMR.PF

(Xue et al., 2007)

CYLD^mr4 is rescued by CYLD^ΔZF.UAS/Scer\GAL4^GMR.PF

(Xue et al., 2007)

Partially rescued by

CYLD^mr4 is partially rescued by CYLD^t5.9

(Xue et al., 2007)

CYLD^mr4 is partially rescued by CYLD^ΔCAP.UAS/Scer\GAL4^GMR.PF

(Xue et al., 2007)

Not rescued by

CYLD^mr4 is not rescued by Scer\GAL4^Tub.PU/CYLD^ΔUCH.UAS

(Xue et al., 2007)

CYLD^mr4 is not rescued by CYLD^ΔUCH.UAS/Scer\GAL4^GMR.PF

(Xue et al., 2007)

Comments

CYLD^t5.9 largely rescues the reduction in lifespan seen in CYLD^mr4 mutant adults (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd).

Expression of CYLD^Scer\UAS.cXa under the control of Scer\GAL4^tub.PU rescues both the shortened lifespan increased sensitivity to paraquat which is seen in CYLD^mr4 mutant adults (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd).

Expression of CYLD^{ΔUCH.Scer\UAS} under the control of Scer\GAL4^tub.PU does not rescue either the shortened lifespan or increased sensitivity to paraquat which is seen in CYLD^mr4 mutant adults (animals homozygous for Df(2L)CYLD^mr4 and carrying P{LX107} to rescue the function of CG13138 and nmd).

Expression of CYLD^Scer\UAS.cXa under the control of Scer\GAL4^GMR.PF suppresses the ability of CYLD^mr4 to suppress the small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

Expression of CYLD^{ΔUCH.Scer\UAS} under the control of Scer\GAL4^GMR.PF has no effect on the ability of CYLD^mr4 to suppress the small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

Expression of CYLD^{ΔCAP.Scer\UAS} under the control of Scer\GAL4^GMR.PF partially suppresses the ability of CYLD^mr4 to suppress the small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

Expression of CYLD^{ΔZF.Scer\UAS} under the control of Scer\GAL4^GMR.PF suppresses the ability of CYLD^mr4 to suppress the small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

(Xue et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CYLD^mr4

dCYLD^mr4

(Xue et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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