FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\seqC022
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General Information
Symbol
Dmel\seqC022
Species
D. melanogaster
Name
FlyBase ID
FBal0261105
Feature type
allele
Associated gene
Dmel\seq
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Araújo and Casanova, 2011)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      seqC022 homozygotes and seqZ1241/seqC022 mutants exhibit branch bifurcations at the tip of the ganglionic branches. Four to seven ganglionic branches exhibit lumenal bifurcations per embryo at stage 15 and in seven to twelve ganglionic branches per embryo at stage 16. These cells adopt a terminal fate and develop their own terminal lumen, causing the observed luminal bifurcations.

      (Araújo and Casanova, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      seqC022 is rescued by seqUAS.cBa/Scer\GAL469B

      (Araújo and Casanova, 2011)

      seqC022/seqZ1241 is rescued by seqUAS.cBa/Scer\GAL469B

      (Araújo and Casanova, 2011)
      Partially rescued by

      seqC022/seqZ1241 is partially rescued by seqUAS.cBa/Scer\GAL4sim.PS

      (Araújo and Casanova, 2011)

      seqC022 is partially rescued by seqUAS.cBa/Scer\GAL4sim.PS

      (Araújo and Casanova, 2011)
      Comments

      Expression of seqScer\UAS.cBa in the ectoderm under the control of Scer\GAL469B rescues the ganglionic branch bifurcation phenotype found in seqC022 and seqZ1241/seqC022 mutants.

      Expression of seqScer\UAS.cBa in midline precursors and glia of seqC022 and seqZ1241/seqC022 mutants under the control of Scer\GAL4sim.PS accomplishes approximately 50% rescue with those embryos that were not fully rescued showing a considerable attenuation of the phenotype.

      (Araújo and Casanova, 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      seqC022
      (Araújo and Casanova, 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)