FlyBase Allele Report: Dmel\seq[Z1241]

General Information

Symbol

Dmel\seq^Z1241

Species

D. melanogaster

Name

FlyBase ID

FBal0261104

Feature type

allele

Associated gene

Dmel\seq

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Araújo and Casanova, 2011)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval ganglionic tracheal branch

(Araújo and Casanova, 2011)

embryonic/larval ganglionic tracheal branch (with seq^C022)

(Araújo and Casanova, 2011)

Detailed Description

Statement

Reference

seq^Z1241 homozygotes and seq^Z1241/seq^C022 mutants exhibit branch bifurcations at the tip of the ganglionic branches. Four to seven ganglionic branches exhibit lumenal bifurcations per embryo at stage 15 and in seven to twelve ganglionic branches per embryo at stage 16. These cells adopt a terminal fate and develop their own terminal lumen, causing the observed luminal bifurcations.

(Araújo and Casanova, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

seq^Z1241 has embryonic/larval ganglionic tracheal branch phenotype, suppressible by bnl[+]/bnl⁰⁰⁸⁵⁷

(Araújo and Casanova, 2011)

seq^Z1241 has embryonic/larval ganglionic tracheal branch phenotype, suppressible by pnt[+]/pnt^Δ88

(Araújo and Casanova, 2011)

NOT suppressed by

Statement

Reference

seq^Z1241 has embryonic/larval ganglionic tracheal branch phenotype, non-suppressible by Scer\GAL4^btl.PS/N^intra.GS.UAS

(Araújo and Casanova, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Removal of one copy of bnl in a bnl⁰⁰⁸⁵⁷ heterozygote rescues the ganglionic branch bifurcation phenotype found in seq^Z1241 heterozygotes.

Removal of one copy of pnt in a pnt^Δ88 heterozygote rescues the ganglionic branch bifurcation phenotype found in seq^Z1241 heterozygotes.

Expression of N^{intra.GS.Scer\UAS} under the control of Scer\GAL4^btl.PS in seq^Z1241 mutant trachea is not sufficient to suppress the ganglionic branch bifurcation phenotype. Activation of N in tracheal cells does not inhibit migration of ganglionic branch cells and is not able to overcome the effects of higher FGF in the ganglionic branches surrounding tissues of seq^Z1241 mutants.

(Araújo and Casanova, 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

seq^Z1241 is rescued by seq^UAS.cBa/Scer\GAL4^69B

(Araújo and Casanova, 2011)

seq^C022/seq^Z1241 is rescued by seq^UAS.cBa/Scer\GAL4^69B

(Araújo and Casanova, 2011)

Partially rescued by

seq^Z1241 is partially rescued by seq^UAS.cBa/Scer\GAL4^sim.PS

(Araújo and Casanova, 2011)

seq^C022/seq^Z1241 is partially rescued by seq^UAS.cBa/Scer\GAL4^sim.PS

(Araújo and Casanova, 2011)

Comments

Expression of seq^Scer\UAS.cBa in the ectoderm under the control of Scer\GAL4^69B rescues the ganglionic branch bifurcation phenotype found in seq^Z1241 and seq^Z1241/seq^C022 mutants.

Expression of seq^Scer\UAS.cBa in midline precursors and glia of seq^Z1241 and seq^Z1241/seq^C022 mutants under the control of Scer\GAL4^sim.PS accomplishes approximately 50% rescue with those embryos that were not fully rescued showing a considerable attenuation of the phenotype.

(Araújo and Casanova, 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

seq^Z1241

(Araújo and Casanova, 2011)

seq^z1241

(Araújo and Casanova, 2011)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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