FlyBase Allele Report: Mmus\Itpr1[IP3-sponge.m30.UAS]

General Information

Symbol

Mmus\Itpr1^{IP3-sponge.m30.UAS}

Species

M. musculus

Name

FlyBase ID

FBal0261173

Feature type

allele

Associated gene

Mmus\Itpr1

Associated Insertion(s)

Carried in Construct

P{UAS-IP3-sponge.m30}

Also Known As

UAS-IP3-sponge, UAS-IP3-Sponge.m30

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Usui-Aoki et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-IP3-sponge.m30}

Cytology

Description

UASt regulatory sequences drive expression of an inositol 1, 4, 5-trisphosphate (IP[[3]]) "sponge" which retains the ability to bind IP[[3]] without exerting any physiological activity, thus titrating cellular IP[[3]]. The sponge sequence consists of a 380 amino acid peptide derived from the ligand binding site of the Mmus\Itpr1 gene which has been mutated to carry the amino acid replacement K508A.

(Usui-Aoki et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mmus\Itpr1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior, with Scer\GAL4^Gr5a.853

(Usui-Aoki et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Mmus\Itpr1^{IP3-sponge.m30.Scer\UAS} under the control of Scer\GAL4^Gr5a.853 changes the sensitivity of flies to sugars, with expression resulting in less of a preference towards trehalose and an increase in consumption of sucrose.

Flies expressing Mmus\Itpr1^{IP3-sponge.m30.Scer\UAS} under the control of Scer\GAL4^Gr5a.853 exhibit a decrease in trehalose consumption at a variety of trehalose concentration.

(Usui-Aoki et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42, Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6 is a suppressor | partially of abnormal neuroanatomy phenotype of Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42, Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6 is a suppressor of abnormal neurophysiology | larval stage phenotype of Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42