FlyBase Allele Report: Dmel\RyR[JF03381]

General Information

Symbol

Dmel\RyR^JF03381

Species

D. melanogaster

Name

FlyBase ID

FBal0242553

Feature type

allele

Associated gene

Dmel\RyR

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03381}

Also Known As

UAS-RyR-RNAi, UAS-RyR RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03381}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03381

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

(Tsubouchi et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing RyR^JF03381 in the fat body under the control of Scer\GAL4^ppl.PP increases lipid droplet size and glyceride level.

(Bi et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

RyR^JF03381, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of SH3PX1^JF02730, Scer\GAL4^esg.PU

(Zhang et al., 2019)

RyR^JF03381, Scer\GAL4^ppl.PP is a suppressor | partially of adult fat body phenotype of Scer\GAL4^ppl.PP, Seipin^null

(Bi et al., 2014)

RyR^JF03381, Scer\GAL4^ppl.PP is a suppressor | partially of lipid droplet phenotype of Scer\GAL4^ppl.PP, Seipin^null

(Bi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of RyR^JF03381 under the control of Scer\GAL4^ppl.PP significantly rescues the reduction in lipid droplet size and glyceride level seen in Seipin^null mutant fat body cells.

(Bi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29445

y¹ v¹; P{TRiP.JF03381}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

RyR^JF03381

RyR^RNAi#3

(Weiss et al., 2022)

Rya-r44F^JF03381

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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