FlyBase Allele Report: Dmel\Asap[B52]

General Information

Symbol

Dmel\Asap^B52

Species

D. melanogaster

Name

FlyBase ID

FBal0410907

Feature type

allele

Associated gene

Dmel\Asap

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Mallik et al., 2026)

Mutagen

CRISPR/Cas9

(Mallik et al., 2026)

Progenitor genotype

Cytology

Description

4725bp deletion in endogenous Asap.

(Mallik et al., 2026)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Mallik et al., 2026)

abnormal neuroanatomy (with Asap^K23)

(Mallik et al., 2026)

abnormal neurophysiology | larval stage (with Asap^K23)

(Mallik et al., 2026)

abnormal size

(Mallik et al., 2026)

abnormal size (with Asap^K23)

(Mallik et al., 2026)

viable

(Mallik et al., 2026)

Phenotype Manifest In

microtubule (with Asap^K23)

(Mallik et al., 2026)

neuromuscular junction (with Asap^K23)

(Mallik et al., 2026)

NMJ bouton | decreased number

(Mallik et al., 2026)

NMJ bouton | decreased number (with Asap^K23)

(Mallik et al., 2026)

presynaptic active zone | increased number (with Asap^K23)

(Mallik et al., 2026)

synapse (with Asap^K23)

(Mallik et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, non-enhanceable by Letm1^HMS01644/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, non-enhanceable by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Suppressed by

Statement

Reference

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by RyR^JF03381/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible | partially by RyR^E4340K

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible | partially by Itpr^90B.0

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by Plc21C^RNAi.UAS.cUa/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^Act5C.PI/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, suppressible by Scer\GAL4^Act5C.PI/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/RyR^JF03381/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

NOT suppressed by

Statement

Reference

Asap^B52/Asap^K23 has abnormal size phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neurophysiology | larval stage phenotype, non-suppressible by Letm1^HMS01644/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^Mef2.247/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, non-suppressible by Scer\GAL4^Mef2.247/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal size phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Other

Statement

Reference

Arf1^T31N.UAS, Asap^B52/Asap^K23, Scer\GAL4^Toll-6-D42 has lethal - all die before end of second instar larval stage phenotype

(Mallik et al., 2026)

Arf1^T31N.UAS, Asap^B52/Asap^K23, Scer\GAL4^Act5C.PI has lethal - all die before end of second instar larval stage phenotype

(Mallik et al., 2026)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, non-enhanceable by Letm1^HMS01644/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, non-enhanceable by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Suppressed by

Statement

Reference

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by RyR^JF03381/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by RyR^E4340K

(Mallik et al., 2026)

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Itpr^90B.0

(Mallik et al., 2026)

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Plc21C^RNAi.UAS.cUa/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has microtubule phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has presynaptic active zone | increased number phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has neuromuscular junction phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, suppressible by Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, suppressible by Scer\GAL4^Act5C.PI/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has microtubule phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has presynaptic active zone | increased number phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has neuromuscular junction phenotype, suppressible by Arf6^KK108126/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/RyR^JF03381/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

NOT suppressed by

Statement

Reference

Asap^B52/Asap^K23 has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by Letm1^HMS01644/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, non-suppressible by Scer\GAL4^Mef2.247/Arf6^T27N.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS

(Mallik et al., 2026)

Asap^B52/Asap^K23 has NMJ bouton | decreased number phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS

(Mallik et al., 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Asap^B52/Asap^K23 is rescued by Scer\GAL4^Act5C.PI/Asap^UASp.cMa

(Mallik et al., 2026)

Asap^B52/Asap^K23 is rescued by Asap^UASp.cMa/Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Not rescued by

Asap^B52/Asap^K23 is not rescued by Scer\GAL4^Mef2.247/Asap^UASp.cMa

(Mallik et al., 2026)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Asap^B52

(Mallik et al., 2026)

Name Synonyms

Secondary FlyBase IDs

References (1)

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