FlyBase Allele Report: Dmel\Arf6[T27N.UAS]

General Information

Symbol

Dmel\Arf6^T27N.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0176396

Feature type

allele

Associated gene

Dmel\Arf6

Associated Insertion(s)

Carried in Construct

P{UAS-Arf6.T27N}

Also Known As

UAS-Arf6^DN

Key Links

Transgenic product class

missense_variant

(Chen et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Chen et al., 2003)

Mutagen

in vitro construct

(Onel et al., 2004, Chen et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-Arf6.T27N}

Cytology

Description

Construct: Amino acid replacement: T27N.

(Chen et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Arf6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic myoblast, with Scer\GAL4^{kirre-rP298-G4}

(Chen et al., 2003)

larval ventral nerve cord commissure | embryonic stage, with Scer\GAL4^rho.PL

(Onel et al., 2004)

retina, with Scer\GAL4^GMR.PF

(Johnson et al., 2011)

Detailed Description

Statement

Reference

Expression of Arf51F^{T27N.Scer\UAS} in the retina under the control of Scer\GAL4^GMR.PF results in patterning defects.

(Johnson et al., 2011)

About 15% of stage 16 Arf51F^{T27N.Scer\UAS}; Scer\GAL4^rho.PL embryos have ventral cords with reduced or missing commissures.

(Onel et al., 2004)

When Arf51F^{T27N.Scer\UAS} is driven by Scer\GAL4^kirre-rP298, myoblast fusion is severely disrupted throughout the internal layer of somatic mesoderm in the embryo, although external muscle fibres are formed in their characteristic position.

(Chen et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal neurophysiology | larval stage phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^T27N.UAS is a suppressor of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^T27N.UAS is a suppressor of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.247/Arf6^T27N.UAS is a non-suppressor of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Mef2.247/Arf6^T27N.UAS is a non-suppressor of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Phenotype Manifest In

Suppressor of

Statement

Reference

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of microtubule phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of presynaptic active zone | increased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of neuromuscular junction phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Arf6^T27N.UAS/Scer\GAL4^Toll-6-D42 is a suppressor of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^T27N.UAS is a suppressor of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.247/Arf6^T27N.UAS is a non-suppressor of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Arf51F^{T27N.Scer\UAS} has no effect on the overproliferation phenotype seen in Scer\GAL4^en-e16E conu^{Scer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG} wing discs.

(Neisch et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ARF6^T27N

(Chen et al., 2003)

Arf51F^{T27N.Scer\UAS}

Arf51F^T27N.UAS

Arf6^T27N.UAS

arf6^DN

(Onel et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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