FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\groAA.UASp
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General Information
Symbol
Dmel\groAA.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0261191
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
P{UASp-gro.AA}
Key Links
Transgenic product class
missense_variant
(Cinnamon et al., 2008)
polypeptide_post_translational_processing_variant
(Cinnamon et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Cinnamon et al., 2008)
polypeptide_post_translational_processing_variant
(Cinnamon et al., 2008)
Mutagen
in vitro construct
(Cinnamon et al., 2008)
Progenitor genotype
Carried in construct
P{UASp-gro.AA}
Cytology
Description

UASp regulatory sequences drive expression of a mutated form of gro, in which alanine residues replace the phospho-acceptor residues within the two rl consensus sites of gro, rendering it unphosphorylatable.

(Cinnamon et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
gro
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of groAA.Scer\UAS.P\T under the control of Scer\GAL4109-30, in combination with gal80[ts] to restrict expression to adulthood, leads to basal stalk defects, including increased number of basal stalk cells and multilayering or elongation in the majority of cases, as compared to controls; clonal follicle stem cells expressing groAA.Scer\UAS.P\T under the control of Scer\GAL4tub.PU exhibit a significant decrease in cell competition capacity, as seen by their increase in clonal extinction as compared to wild-type control clones.

      (Johnston et al., 2016)

      Maternal expression of groAA.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in 86% loss of the intermediate neuroblast column of the neuroectoderm in embryos.

      (Helman et al., 2011)

      Maternal expression of groAA.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in a low hatching rate. 30.5% of unhatched larvae show strong reduction or even loss of the filzkorper.

      (Cinnamon et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of groAA.Scer\UAS.P\T partially suppresses the basal stalk defects induced by the expression of btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4109-30.

      (Johnston et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GroAA
      (Cinnamon et al., 2008)
      groAA.Scer\UAS.P\T
      groAA.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)