FlyBase Allele Report: Dmel\Dsor1[HMS00145]

General Information

Symbol

Dmel\Dsor1^HMS00145

Species

D. melanogaster

Name

FlyBase ID

FBal0263142

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00145}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00145}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00145

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cyst cell of testis | absent, with Scer\GAL4^NP1624

(Zheng et al., 2021)

cyst progenitor cell | absent, with Scer\GAL4^NP1624

(Zheng et al., 2021)

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

male fusome, with Scer\GAL4^bam.PU

(Yu et al., 2021)

male fusome, with Scer\GAL4^NP1624

(Zheng et al., 2021)

male germline cell, with Scer\GAL4^bam.PU

(Yu et al., 2021)

Detailed Description

Statement

Reference

Females heterozygous for Dsor1^HMS00145 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Dsor1^HMS00145 males results in: 0% hatching; egg/embryonic phenotype: blobbed phenotype; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of increased size | oogenesis phenotype of Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

NOT Suppressor of

Statement

Reference

Dsor1^HMS00145/Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor of decreased cell number | recessive | embryonic stage phenotype of gcl^rev390

(Pae et al., 2017)

Other

Statement

Reference

Dsor1^HMS00145, Scer\GAL4^bam.PU, bam^Δ86 has increased occurrence of cell division | spermatogenesis phenotype

(Yu et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dsor1^HMS00145, Scer\GAL4^bam.PU has male germline cell phenotype, enhanceable by bam^Δ86

(Yu et al., 2021)

Suppressor of

Statement

Reference

Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of germarium phenotype of Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

Dsor1^HMS00145, Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of spectrosome | oogenesis phenotype of Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

NOT Suppressor of

Statement

Reference

Dsor1^HMS00145/Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor of germline cell | embryonic stage phenotype of gcl^rev390

(Pae et al., 2017)

Other

Statement

Reference

Dsor1^HMS00145, Scer\GAL4^bam.PU, bam^Δ86 has male germline cell phenotype

(Yu et al., 2021)

Dsor1^HMS00145, Scer\GAL4^bam.PU, bam^Δ86 has male fusome phenotype

(Yu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Dsor1^HMS00145 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} does not suppress the decreased primordial germ cells in gcl^rev390 homozygous early embryos (i.e. mitotic cycles 12/13).

(Pae et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34830